miRBase entry: hsa-mir-152

Stem-loop hsa-mir-152

Homo sapiens hsa-mir-152 precursor miRNA
Gene family
MIPF0000056; mir-148

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR152 is a microRNA that has been found to play a role in various cellular processes [PMC9994484]. In a study, it was observed that in cells exposed to lipopolysaccharide (LPS) in the presence of MK1903, the expression of miR‐128, miR‐425, and miR‐130 was significantly increased compared to both the LPS and vehicle groups [PMC9994484]. On the other hand, the expression of miR‐19, MIR152, miR‐301, and miR‐29 was rescued to control levels [PMC9994484]. Additionally, it has been discovered that lncRNA plasmacytoma variant translocation 1 (PVT1) triggers liver epithelial-mesenchymal transition (EMT) by competitively binding to MIR152 [PMC8990740]. These findings suggest that MIR152 may have a regulatory role in cellular responses to LPS exposure and liver EMT [PMC9994484][PMC8990740[PMC8990740]. Further research is needed to fully understand the mechanisms by which MIR152 functions and its potential implications in various biological processes [PMC9994484][PMC8990740[PMC8990740].

Literature search
146 open access papers mention hsa-mir-152
(888 sentences)


277009 reads, 813 reads per million, 150 experiments

u    cc  c              G  A    CC    cgg   c 
 gucc  cc ggcccAGGUUCUGU AU CACU  GACU   gcu u
 ||||  || |||||||||||||| || ||||  ||||   |||  
 cagg  gg ccgGGUUCAAGACA UA GUGA  CUga   cga g
c    aa  c              G  C    --    ---   g 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context
chr17: 48037161-48037247 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-152
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-152 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-152-3p

Accession MIMAT0000438
Description Homo sapiens hsa-miR-152-3p mature miRNA
Evidence experimental
cloned [2-3], Illumina [4-5]
Database links
Predicted targets

Mature hsa-miR-152-5p

Accession MIMAT0026479
Description Homo sapiens hsa-miR-152-5p mature miRNA
Evidence experimental
Illumina [5]


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  4. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  5. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45