Stem-loop hsa-mir-9-1

Accession

MI0000466

Symbol

HGNC: MIR9-1

Description

Homo sapiens hsa-mir-9-1 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR9-1 is a microRNA implicated in various cellular processes, including apoptosis and cell proliferation [PMC9220270]. In the context of lung cancer, MIR9-1 has been identified as having a proapoptotic effect, which suggests that it can promote programmed cell death in cancerous cells [PMC9220270]. Additionally, MIR9-1 is involved in the suppression of cell proliferation, and this function is mediated through its interaction with the UHRF1 protein [PMC9220270]. UHRF1 has been known to play a role in gene expression regulation by interacting with epigenetic marks. The hypermethylation of MIR9-1 gene has been associated with an increased relative risk of death in lung cancer patients [PMC8835734]. This epigenetic alteration can lead to the downregulation of MIR9-1 expression, which may contribute to cancer progression by reducing its proapoptotic and antiproliferative effects. The study highlights the significance of MIR9-1 as a potential biomarker for lung cancer prognosis and as a target for therapeutic interventions [PMC8835734].

Literature search

547 open access papers mention hsa-mir-9-1
(3386 sentences)

Sequence

663527 reads, 2789 reads per million, 111 experiments

cgggguugguuguuaUCUUUGGUUAUCUAGCUGUAUGAgugguguggagucuucAUAAAGCUAGAUAACCGAAAGUaaaaauaacccca
.(((((((....((((.(((((((((((((((.((((((.(.(....).).)))))).))))))))))))))).))))...))))))).

Structure

c       guug    C               G      u g g 
 gggguug    uuaU UUUGGUUAUCUAGCU UAUGAg g u u
 |||||||    |||| ||||||||||||||| |||||| | |  
 ccccaau    aaUG AAGCCAAUAGAUCGA AUAcuu u a g
a       -aaa    A               A      c g g 

Annotation confidence High

Genome context

chr1: 156420341-156420429 [-]

Disease association

hsa-mir-9-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-9-5p

• Accession: MIMAT0000441
• Description: Homo sapiens hsa-miR-9-5p mature miRNA
• Sequence: 16 - UCUUUGGUUAUCUAGCUGUAUGA - 38
• Evidence: experimental ; cloned [2]

Mature hsa-miR-9-3p

• Accession: MIMAT0000442
• Description: Homo sapiens hsa-miR-9-3p mature miRNA
• Sequence: 55 - AUAAAGCUAGAUAACCGAAAGU - 76
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739