Stem-loop hsa-mir-185

Accession

MI0000482

Symbol

HGNC: MIR185

Description

Homo sapiens hsa-mir-185 precursor miRNA mir-185

Gene
family

RF00771; mir-185

Literature search

118 open access papers mention hsa-mir-185
(783 sentences)

Sequence

507017 reads, 1786 reads per million, 140 experiments

agggggcgagggauUGGAGAGAAAGGCAGUUCCUGAugguccccuccccAGGGGCUGGCUUUCCUCUGGUCcuucccuccca
.(((((.((((((((((((.(((((.(((((((((..((......)).))))))))).))))))))))))))))).))))).

Structure

a     c            A     G         Au  uc 
 ggggg gagggauUGGAG GAAAG CAGUUCCUG  gg  c
 ||||| |||||||||||| ||||| |||||||||  ||   
 cccuc cuucCUGGUCUC CUUUC GUCGGGGAc  cc  c
a     c            -     G         -c  uc 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Its expression was later verified in human BC-1 cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr22: 20033139-20033220 [+]

Disease association

hsa-mir-185 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-185-5p

• Accession: MIMAT0000455
• Description: Homo sapiens hsa-miR-185-5p mature miRNA
• Sequence: 15 - UGGAGAGAAAGGCAGUUCCUGA - 36
• Evidence: experimental ; cloned [2-4], Illumina [5]

Mature hsa-miR-185-3p

• Accession: MIMAT0004611
• Description: Homo sapiens hsa-miR-185-3p mature miRNA
• Sequence: 50 - AGGGGCUGGCUUUCCUCUGGUC - 71
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 20158877
   Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
   Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
   BMC Genomics (2010) 11:S6


4. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


5. PubMed ID: 15800047
   Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
   "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
   "Proc Natl Acad Sci U S A (2005) 102:5570-5575