Stem-loop mmu-let-7b

Accession

MI0000558

Symbol

MGI: Mirlet7b

Description

Mus musculus mmu-let-7b precursor miRNA

Literature search

448 open access papers mention mmu-let-7b
(2571 sentences)

Sequence

10485636 reads, 16884 reads per million, 107 experiments

gcagggUGAGGUAGUAGGUUGUGUGGUUucagggcagugauguugccccuccgaagauaaCUAUACAACCUACUGCCUUCCCuga
.(((((.(((((((((((((((((((((((.((((((.....)))))).......)).)))))))))))))))))))))))))).

Structure

g     U                     -  ------a      u 
 caggg GAGGUAGUAGGUUGUGUGGUU uc       gggcag g
 ||||| ||||||||||||||||||||| ||       |||||| a
 guCCC UUCCGUCAUCCAACAUAUCaa ag       cccguu u
a     -                     u  aagccuc      g 

Annotation confidence Medium

Genome context

chr15: 85707319-85707403 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-let-7b

Mature mmu-let-7b-5p

• Accession: MIMAT0000522
• Description: Mus musculus mmu-let-7b-5p mature miRNA
• Sequence: 7 - UGAGGUAGUAGGUUGUGUGGUU - 28
• Evidence: experimental ; cloned [1-4], Illumina [5-6]

Mature mmu-let-7b-3p

• Accession: MIMAT0004621
• Description: Mus musculus mmu-let-7b-3p mature miRNA
• Sequence: 61 - CUAUACAACCUACUGCCUUCCC - 82
• Evidence: experimental ; cloned [4], Illumina [5-6]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


4. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


5. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


6. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009