Stem-loop mmu-mir-351

Accession

MI0000643

Symbol

MGI: Mir351

Description

Mus musculus mmu-mir-351 precursor miRNA mir-351

Gene
family

RF00805; mir-351

Literature search

28 open access papers mention mmu-mir-351
(207 sentences)

Sequence

555688 reads, 1339 reads per million, 104 experiments

cauggcaccuccguuUCCCUGAGGAGCCCUUUGAGCCUGgagugaaaaaaaaaaacaGGUCAAGAGGCGCCUGGGAACuggagaagaguguuaaacuuc
..(((((((((((.(((((..(((.(((.(((((.((((................))))))))).))).)))))))).)))))....))))))......

Structure

----ca      ----     u     UG   A   C     G    gagugaa 
      uggcac    cuccg uUCCC  AGG GCC UUUGA CCUG       a
      ||||||    ||||| |||||  ||| ||| ||||| ||||        
      auugug    gaggu AAGGG  UCC CGG GAACU GGac       a
cuucaa      agaa     C     --   G   A     -    aaaaaaa 

Annotation confidence High

Comments

The predominant miRNA cloned by Langraf et al. has a 3' terminal U residue, which is incompatible with the genome sequence [1].

Genome context

chrX: 53053255-53053353 [-]

Clustered miRNAs

6 other miRNAs are < 10 kb from mmu-mir-351

Mature mmu-miR-351-5p

• Accession: MIMAT0000609
• Description: Mus musculus mmu-miR-351-5p mature miRNA
• Sequence: 16 - UCCCUGAGGAGCCCUUUGAGCCUG - 39
• Evidence: experimental ; cloned [1], Illumina [2,4]

Mature mmu-miR-351-3p

• Accession: MIMAT0017042
• Description: Mus musculus mmu-miR-351-3p mature miRNA
• Sequence: 58 - GGUCAAGAGGCGCCUGGGAAC - 78
• Evidence: experimental ; 454 [3], Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 20668074
   Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68
   "Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H"
   "J Virol (2010) 84:10266-10275