Stem-loop mmu-mir-200c

Accession

MI0000694

Symbol

MGI: Mir200c

Description

Mus musculus mmu-mir-200c precursor miRNA mir-8

Gene
family

RF00241; mir-8

Literature search

303 open access papers mention mmu-mir-200c
(2882 sentences)

Sequence

101927 reads, 371 reads per million, 102 experiments

cccuCGUCUUACCCAGCAGUGUUUGGgugcugguugggagucucUAAUACUGCCGGGUAAUGAUGGAgg
.(((((((((((((.((((((((.(((.(((.......)))))).)))))))).)))))).))).))))

Structure

c    -   -      A        U   u   gg 
 ccuC GUC UUACCC GCAGUGUU GGg gcu  u
 |||| ||| |||||| |||||||| ||| |||  u
 ggAG UAG AAUGGG CGUCAUAA cuc uga  g
-    G   U      C        U   -   gg 

Annotation confidence High

Comments

Mouse mir-200c is predicted [3] based on homology to a cloned miR from human (MIR:MI0000650) [1]. Its expression in mouse was later verified independently [2,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr6: 124718322-124718390 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-200c

Mature mmu-miR-200c-5p

• Accession: MIMAT0004663
• Description: Mus musculus mmu-miR-200c-5p mature miRNA
• Sequence: 5 - CGUCUUACCCAGCAGUGUUUGG - 26
• Evidence: experimental ; cloned [4], Illumina [5-6]

Mature mmu-miR-200c-3p

• Accession: MIMAT0000657
• Description: Mus musculus mmu-miR-200c-3p mature miRNA
• Sequence: 45 - UAAUACUGCCGGGUAAUGAUGGA - 67
• Evidence: experimental ; cloned [2,4], Illumina [5-6]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73