Stem-loop mmu-mir-214

Accession

MI0000698

Symbol

MGI: Mir214

Description

Mus musculus mmu-mir-214 precursor miRNA mir-214

Gene
family

RF00660; mir-214

Literature search

120 open access papers mention mmu-mir-214
(1855 sentences)

Sequence

97722 reads, 2163 reads per million, 88 experiments

ggccuggcuggacagaguugucaugugucUGCCUGUCUACACUUGCUGUGCagaacauccgcucaccuguACAGCAGGCACAGACAGGCAGUcacaugacaacccagccu
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).

Structure

ggccu      acaga           u          ACA            aacau 
     ggcugg     guugucaugug cUGCCUGUCU   CUUGCUGUGCag     c
     ||||||     ||||||||||| ||||||||||   ||||||||||||     c
     ccgacc     caacaguacac GACGGACAGA   GGACGACAuguc     g
----u      -----           U          CAC            cacuc 

Annotation confidence High

Comments

Mouse mir-214 is predicted [2] based on homology to a reported miR from human (MIR:MI0000290) [1]. Its expression was later verified by cloning [3].

Genome context

chr1: 162223368-162223477 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-214

Mature mmu-miR-214-5p

• Accession: MIMAT0004664
• Description: Mus musculus mmu-miR-214-5p mature miRNA
• Sequence: 30 - UGCCUGUCUACACUUGCUGUGC - 51
• Evidence: experimental ; cloned [3], Illumina [4-5]

Mature mmu-miR-214-3p

• Accession: MIMAT0000661
• Description: Mus musculus mmu-miR-214-3p mature miRNA
• Sequence: 71 - ACAGCAGGCACAGACAGGCAGU - 92
• Evidence: experimental ; cloned [3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


5. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73