Stem-loop mmu-mir-218-1

Accession

MI0000700

Symbol

MGI: Mir218-1

Description

Mus musculus mmu-mir-218-1 precursor miRNA mir-218

Gene
family

RF00255; mir-218

Literature search

72 open access papers mention mmu-mir-218-1
(607 sentences)

Sequence

107885 reads, 1446 reads per million, 78 experiments

gugauaauggagcgagauuuucugUUGUGCUUGAUCUAACCAUGUgcuugcgagguaugagaaAAACAUGGUUCCGUCAAGCACCauggaacgucacgcagcuuucuaca
(((..((.(..(((.(((.((((((.(((((((((..((((((((....................))))))))..))))))))).)))))).))).)))..)))..))).

Structure

-   au  u ga   a   u      U         CU        gcuugcgag 
 gug  aa g  gcg gau uucugU GUGCUUGAU  AACCAUGU         g
 |||  || |  ||| ||| |||||| |||||||||  ||||||||          
 cau  uu c  cgc cug aaggua CACGAACUG  UUGGUACA         u
a   cu  - ga   a   c      C         CC        AAaagagua 

Annotation confidence High

Comments

Mouse miR-218 is predicted [2] based on homology to a reported miR from human (MIR:MI0000294) [1]. Its expression was later verified by cloning [3].

Genome context

chr5: 48223942-48224051 [+]

Mature mmu-miR-218-5p

• Accession: MIMAT0000663
• Description: Mus musculus mmu-miR-218-5p mature miRNA
• Sequence: 25 - UUGUGCUUGAUCUAACCAUGU - 45
• Evidence: experimental ; cloned [3], Illumina [4-5]

Mature mmu-miR-218-1-3p

• Accession: MIMAT0004665
• Description: Mus musculus mmu-miR-218-1-3p mature miRNA
• Sequence: 64 - AAACAUGGUUCCGUCAAGCACC - 85
• Evidence: experimental ; cloned [3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


5. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73