Stem-loop mmu-mir-128-2

Accession

MI0000726

Symbol

MGI: Mir128-2

Description

Mus musculus mmu-mir-128-2 precursor miRNA mir-128

Gene
family

RF00649; mir-128

Literature search

76 open access papers mention mmu-mir-128-2
(653 sentences)

Sequence

640476 reads, 1672 reads per million, 105 experiments

cagugggaagGGGGGCCGAUGCACUGUAAGAGAgugaguagcaggucUCACAGUGAACCGGUCUCUUUcccuacug
(((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).)))))))

Structure

       a          AUG      AA    g gag 
caguggg agGGGGGCCG   CACUGU  GAGA u   u
||||||| ||||||||||   ||||||  |||| |    
gucaucc UUUCUCUGGC   GUGACA  CUcu g   a
       c          CAA      --    g acg 

Annotation confidence High

Comments

The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical [3]. The sequences are therefore renamed mir-128-1 and mir-128-2.

Genome context

chr9: 112118636-112118711 [-]

Mature mmu-miR-128-3p

• Accession: MIMAT0000140
• Description: Mus musculus mmu-miR-128-3p mature miRNA
• Sequence: 48 - UCACAGUGAACCGGUCUCUUU - 68
• Evidence: experimental ; cloned [3], Illumina [4-5]

Mature mmu-miR-128-2-5p

• Accession: MIMAT0017069
• Description: Mus musculus mmu-miR-128-2-5p mature miRNA
• Sequence: 11 - GGGGGCCGAUGCACUGUAAGAGA - 33
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009