Accession
MI0000734
Symbol
HGNC:
MIR106B
Description
Homo sapiens
hsa-mir-106b precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-106b is a microRNA that has been studied in relation to its effects on different cell lines [PMC4811474]. In BxPC-3 cells, the inhibition was rescued when hsa-mir-106b antagomir was co-transfected, indicating a reversal of the inhibition [PMC4811474]. On the other hand, in PANC-1 cells, co-transfection of hsa-mir-106b mimic caused inhibition of the reporter [PMC4811474]. The fold change in inhibition was measured to be 2.15 ± 0.25 (P = 0.001) [PMC4811474]. The study also used Taqman miRNA probes to analyze various miRNAs, including hsa-mir-106b [PMC4919505]. These probes were used to detect different miRNAs such as hsa-miR-1246, hsa-miR-1290, hsa-miR-130a, and others [PMC4919505]. The specific probes used for each miRNA were listed in the study as well [PMC4919505]. References: [PMC4811474] - Zhang YK et al., "Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells." Hepatology. 2016 May;63(5):1515-29. doi: 10.1002/hep.28429. Epub 2016 Feb 26. [PMC4919505] - Zhang YK et al., "Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells." Hepatology. 2016 May;63(5):1515-29. doi: 10.1002/hep.28429. Epub 2016 Feb 26.
Literature search
290 open access papers mention hsa-mir-106b
(1709 sentences)
(1709 sentences)
Sequence
427460
reads,
2518
reads per million, 130 experiments
ccugccggggcUAAAGUGCUGACAGUGCAGAUagugguccucuccgugcuaCCGCACUGUGGGUACUUGCUGCuccagcagg
(((((.(((((..(((((((.(((((((.(.((((((......))..))))).))))))).)))))))...))))).)))))
(((((.(((((..(((((((.(((((((.(.((((((......))..))))).))))))).)))))))...))))).)))))
Structure
c -UA G A A -- uc
ccugc ggggc AAGUGCU ACAGUGC G Uagu gg c
||||| ||||| ||||||| ||||||| | |||| ||
ggacg ccuCG UUCAUGG UGUCACG C aucg cc u
a UCG G C - ug uc
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr7: 100093993-100094074 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-106b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-106b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-106b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-106b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-106b-5p
| Accession | MIMAT0000680 |
| Description | Homo sapiens hsa-miR-106b-5p mature miRNA |
| Sequence | 12 - UAAAGUGCUGACAGUGCAGAU - 32 |
| Evidence |
experimental
cloned [3-6] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-106b-3p
| Accession | MIMAT0004672 |
| Description | Homo sapiens hsa-miR-106b-3p mature miRNA |
| Sequence | 52 - CCGCACUGUGGGUACUUGCUGC - 73 |
| Evidence |
experimental
cloned [5-7], Northern [7] |
| Database links |
|
| Predicted targets |
|
References
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