Accession
MI0000734
Symbol
HGNC:
MIR106B
Description
Homo sapiens
hsa-mir-106b precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-106b is a microRNA involved in the regulation of gene expression in various cellular processes [PMC4919505]. In BxPC-3 cells, the inhibition of gene expression was reversed upon the introduction of a hsa-mir-106b antagomir, indicating that hsa-mir-106b plays a role in suppressing gene expression [PMC4811474]. Conversely, when hsa-mir-106b mimic was co-transfected into PANC-1 cells, there was a significant inhibition of the reporter gene by more than two-fold [PMC4811474]. This suggests that hsa-mir-106b can function as an oncomiR or tumor suppressor depending on the cellular context. The use of Taqman miRNA probes for hsa-mir-106b (000442) among others facilitates the study and quantification of microRNAs and their role in cellular functions [PMC4919505].
Literature search
290 open access papers mention hsa-mir-106b
(1709 sentences)
(1709 sentences)
Sequence
427460
reads,
1755
reads per million, 130 experiments
ccugccggggcUAAAGUGCUGACAGUGCAGAUagugguccucuccgugcuaCCGCACUGUGGGUACUUGCUGCuccagcagg
(((((.(((((..(((((((.(((((((.(.((((((......))..))))).))))))).)))))))...))))).)))))
(((((.(((((..(((((((.(((((((.(.((((((......))..))))).))))))).)))))))...))))).)))))
Structure
c -UA G A A -- uc
ccugc ggggc AAGUGCU ACAGUGC G Uagu gg c
||||| ||||| ||||||| ||||||| | |||| ||
ggacg ccuCG UUCAUGG UGUCACG C aucg cc u
a UCG G C - ug uc
Annotation confidence
Medium
Do you think this miRNA is real?
Genome context
chr7: 100093993-100094074 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-106b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-106b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-106b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-106b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-106b-5p
| Accession | MIMAT0000680 |
| Description | Homo sapiens hsa-miR-106b-5p mature miRNA |
| Sequence | 12 - UAAAGUGCUGACAGUGCAGAU - 32 |
| Evidence |
experimental
cloned [3-6] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-106b-3p
| Accession | MIMAT0004672 |
| Description | Homo sapiens hsa-miR-106b-3p mature miRNA |
| Sequence | 52 - CCGCACUGUGGGUACUUGCUGC - 73 |
| Evidence |
experimental
cloned [5-7], Northern [7] |
| Database links |
|
| Predicted targets |
|
References
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