miRBase entry: hsa-mir-423

Stem-loop hsa-mir-423

Homo sapiens hsa-mir-423 precursor miRNA
Gene family
MIPF0000329; mir-423

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR423 is one of the 16 candidate miRNAs that have been studied for their potential involvement in diabetes [PMC7463887]. It is a type of miRNA that has been found to be altered in the plasma/serum of diabetic patients [PMC7463887]. In a study involving 47 T2D patients and 22 healthy subjects, the expression of MIR423, along with other miRNAs such as mir29a, mir34b, Xpo5, and several others, was found to be significantly different in leukoplakia tissues compared to control tissues [PMC4035900]. However, the expression of these genes was not modulated by genotypes at SNPs [PMC4035900]. This study aimed to investigate the potential involvement of these candidate miRNAs in diabetic retinopathy [PMC7463887]. The researchers analyzed plasma/serum samples from T2D patients with and without retinopathy as well as healthy subjects [PMC7463887'>PMC7463887]. The findings suggest that MIR423 and other miRNAs may play a role in the development or progression of diabetic retinopathy [PMC7463887]. Further research is needed to fully understand the mechanisms by which these miRNAs contribute to the pathogenesis of diabetes and its complications [PMC7463887].

Literature search
111 open access papers mention hsa-mir-423
(452 sentences)


1378783 reads, 5810 reads per million, 159 experiments

-----auaa       u            -AG   G    A     cua 
         aggaagu aggcUGAGGGGC   AGA CGAG CUUUu   u
         ||||||| ||||||||||||   ||| |||| |||||   u
         uccuucg ucUGACUCCCCG   UCU GCUC GAaaa   u
cgcgcccaa       u            GAG   G    -     ccu 

Annotation confidence High
Do you think this miRNA is real?
miR-423 (renamed miR-423-3p here) is expressed in human promyelocytic leukemia (HL-60) cells [1]. The level of expression was shown to be up-regulated 48 hours after TPA-induction. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr17: 30117079-30117172 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-423
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-423 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-423-5p

Accession MIMAT0004748
Description Homo sapiens hsa-miR-423-5p mature miRNA
Evidence experimental
cloned [2-4], Northern [4], Illumina [5]
Database links
Predicted targets

Mature hsa-miR-423-3p

Accession MIMAT0001340
Description Homo sapiens hsa-miR-423-3p mature miRNA
Evidence experimental
cloned [1-2], Northern [1]
Database links
Predicted targets


  1. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  5. PubMed ID: 18230126
    New miRNAs cloned from neuroblastoma
    "Afanasyeva EA, Hotz-Wagenblatt A, Glatting KH, Westermann F"
    "BMC Genomics (2008) 9:52