Accession
MI0001445
Symbol
HGNC:
MIR423
Description
Homo sapiens
hsa-mir-423 precursor miRNA mir-423
Gene
family?
family?
RF00870;
mir-423
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR423 is a microRNA, a small non-coding RNA molecule, which is involved in the regulation of gene expression [PMC7463887]. It was not found to be modulated by genotypes at single nucleotide polymorphisms (SNPs) in a study comparing its expression in leukoplakia tissues to control tissues [PMC4035900]. However, its expression was significantly different when leukoplakia tissues were compared with control tissues, suggesting a potential role in the pathogenesis of this condition [PMC4035900]. Additionally, MIR423 was included in a panel of 16 candidate microRNAs that were previously reported to be altered in the plasma/serum of diabetic patients [PMC7463887]. This panel was analyzed to assess the potential involvement of these microRNAs in diabetic retinopathy among type 2 diabetes (T2D) patients with varying degrees of retinopathy and healthy subjects [PMC7463887]. The study aimed to understand better the molecular mechanisms underlying diabetic complications and potentially identify biomarkers for disease progression and prognosis [PMC7463887].
Literature search
111 open access papers mention hsa-mir-423
(452 sentences)
(452 sentences)
Sequence
1378741
reads,
3190
reads per million, 159 experiments
auaaaggaaguuaggcUGAGGGGCAGAGAGCGAGACUUUucuauuuuccaaaAGCUCGGUCUGAGGCCCCUCAGUcuugcuuccuaacccgcgc
....(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).))))))).........
....(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).))))))).........
Structure
-----auaa u -AG G A cua
aggaagu aggcUGAGGGGC AGA CGAG CUUUu u
||||||| |||||||||||| ||| |||| ||||| u
uccuucg ucUGACUCCCCG UCU GCUC GAaaa u
cgcgcccaa u GAG G - ccu
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
miR-423 (renamed miR-423-3p here) is expressed in human promyelocytic leukemia (HL-60) cells [1]. The level of expression was shown to be up-regulated 48 hours after TPA-induction. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr17: 30117079-30117172 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-423
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-423 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-423-5p
| Accession | MIMAT0004748 |
| Description | Homo sapiens hsa-miR-423-5p mature miRNA |
| Sequence | 17 - UGAGGGGCAGAGAGCGAGACUUU - 39 |
| Evidence |
experimental
cloned [2-4], Northern [4], Illumina [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-423-3p
| Accession | MIMAT0001340 |
| Description | Homo sapiens hsa-miR-423-3p mature miRNA |
| Sequence | 53 - AGCUCGGUCUGAGGCCCCUCAGU - 75 |
| Evidence |
experimental
cloned [1-2], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
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