Stem-loop mmu-mir-434

Accession

MI0001526

Symbol

MGI: Mir434

Description

Mus musculus mmu-mir-434 precursor miRNA mir-434

Gene
family

RF00941; mir-434

Literature search

19 open access papers mention mmu-mir-434
(115 sentences)

Sequence

821384 reads, 1548 reads per million, 93 experiments

ucgacucuggguuugaaccaaaGCUCGACUCAUGGUUUGAACCAuuacuuaauucguggUUUGAACCAUCACUCGACUCCUgguucgaaccauc
.........(((((((((((.((.((((...((((((((((((((..........))))))))))))))...))))))..)))))))))))...

Structure

ucgacucug           -a  C    CUC              uacu 
         gguuugaacca  aG UCGA   AUGGUUUGAACCAu    u
         |||||||||||  || ||||   ||||||||||||||     
         ccaagcuuggU  UC AGCU   UACCAAGUUUggug    a
------cua           CC  -    CAC              cuua 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr12: 109594506-109594599 [+]

Clustered miRNAs

12 other miRNAs are < 10 kb from mmu-mir-434

Mature mmu-miR-434-5p

• Accession: MIMAT0001421
• Description: Mus musculus mmu-miR-434-5p mature miRNA
• Sequence: 23 - GCUCGACUCAUGGUUUGAACCA - 44
• Evidence: experimental ; PCR [1], cloned [2-3], Illumina [4-5]

Mature mmu-miR-434-3p

• Accession: MIMAT0001422
• Description: Mus musculus mmu-miR-434-3p mature miRNA
• Sequence: 60 - UUUGAACCAUCACUCGACUCCU - 81
• Evidence: experimental ; PCR [1], cloned [2-3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 15854907
   RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus
   "Davis E, Caiment F, Tordoir X, Cavaille J, Ferguson-Smith A, Cockett N, Georges M, Charlier C"
   "Curr Biol (2005) 15:743-749


5. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267