Stem-loop hsa-mir-450a-2

Accession

MI0003187

Symbol

HGNC: MIR450A2

Description

Homo sapiens hsa-mir-450a-2 precursor miRNA mir-450

Gene
family

RF00708; mir-450

Literature search

21 open access papers mention hsa-mir-450a-2
(43 sentences)

Sequence

23128 reads, 247 reads per million, 112 experiments

ccaaagaaagaugcuaaacuauUUUUGCGAUGUGUUCCUAAUAUguaauauaaauguAUUGGGGACAUUUUGCAUUCAUaguuuuguaucaauaauaugg
.........(((((.(((((((...(((((.(((((((((((((((.......))))))))))))))).)))))...))))))).)))))..........

Structure

-ccaaagaaa     u       UUU     U               aa 
          gaugc aaacuau   UGCGA GUGUUCCUAAUAUgu  u
          ||||| |||||||   ||||| |||||||||||||||  a
          cuaug uuugaUA   ACGUU UACAGGGGUUAugua  u
gguauaauaa     u       CUU     U               aa 

Annotation confidence Medium

Genome context

chrX: 134540508-134540607 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-450a-2

Disease association

hsa-mir-450a-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-450a-5p

• Accession: MIMAT0001545
• Description: Homo sapiens hsa-miR-450a-5p mature miRNA
• Sequence: 23 - UUUUGCGAUGUGUUCCUAAUAU - 44
• Evidence: experimental ; array-cloned [1,3], cloned [1,4]

Mature hsa-miR-450a-2-3p

• Accession: MIMAT0031074
• Description: Homo sapiens hsa-miR-450a-2-3p mature miRNA
• Sequence: 58 - AUUGGGGACAUUUUGCAUUCAU - 79
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


4. PubMed ID: 15735639
   Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
   "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
   "Nature (2005) 434:338-345