Stem-loop mmu-mir-1249

Accession

MI0004132

Symbol

MGI: Mir1249

Description

Mus musculus mmu-mir-1249 precursor miRNA mir-1249

Gene
family

RF01918; mir-1249

Literature search

8 open access papers mention mmu-mir-1249
(11 sentences)

Sequence

6746 reads, 68 reads per million, 94 experiments

cgauucuuguuugcguggggAGGAGGGAGGGGAUGGGCCAAGUUCccuaugccuggaACGCCCUUCCCCCCCUUCUUCAccuggcgaacuccuacucg
(((.....((((((..(((((((((((.(((((.((((...(((((........))))))))).)))))))))))))).))..))))))......)))

Structure

   -uucuu      gu  -         A     U    CAA     cua 
cga      guuugc  gg ggAGGAGGG GGGGA GGGC   GUUCc   u
|||      ||||||  || ||||||||| ||||| ||||   |||||    
gcu      caagcg  cc CUUCUUCCC CCCCU CCCG   CAagg   g
   cauccu      gu  A         -     U    ---     ucc 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al [1], and confirmed later in mouse ES cells [2].

Genome context

chr15: 84951526-84951623 [-]

Mature mmu-miR-1249-5p

• Accession: MIMAT0014804
• Description: Mus musculus mmu-miR-1249-5p mature miRNA
• Sequence: 21 - AGGAGGGAGGGGAUGGGCCAAGUUC - 45
• Evidence: experimental ; Illumina [3]

Mature mmu-miR-1249-3p

• Accession: MIMAT0010560
• Description: Mus musculus mmu-miR-1249-3p mature miRNA
• Sequence: 58 - ACGCCCUUCCCCCCCUUCUUCA - 79
• Evidence: experimental ; RAKE [1], 454 [2], Illumina [3]

References

1. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


3. PubMed ID: 17989215
   RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
   "Calabrese JM, Seila AC, Yeo GW, Sharp PA"
   "Proc Natl Acad Sci U S A (2007) 104:18097-18102