Accession
MI0004741
Description
Bos taurus
bta-mir-20a precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
bta-mir-20a is a microRNA (miRNA) that has been identified as a master regulator and is upregulated in certain bovine conditions [PMC9445238]. It has been characterized as differentially expressed (DE) with a fold change (FC) less than 2.0 [PMC5736867]. Due to its stable expression, bta-mir-20a is used as an endogenous control in quantitative real-time PCR (qRT-PCR) assays, alongside other miRNAs like bta-miR-181a, bta-miR-30b-5p, and bta-miR-378 [PMC6691986]. It has been validated as a regulator of the PTEN gene in bovine granulosa cells and is associated with the PI3K-Akt signaling pathway's activity in follicular cells (FCs), influencing oocyte quality [PMC5602670]. The expression of bta-mir-20a was found to be significantly higher in FCs from follicles that led to oocyte cleavage, indicating its potential role in oocyte developmental potential [PMC5602670]. Despite its stable expression across different fertility conditions, it was differentially expressed in milk and plasma during early pregnancy in cattle [PMC6418173], but it did not follow the same expression trend as other miRNAs within its cluster during early pregnancy stages [PMC5325256].
Literature search
22 open access papers mention bta-mir-20a
(93 sentences)
(93 sentences)
Sequence
6484
reads,
99
reads per million, 70 experiments
guagcacUAAAGUGCUUAUAGUGCAGGUAGuguuuaguuaucuacugcauuaugagcacuuaaaguacugc
((((.(((.(((((((((((((((((.(((...........))))))))))))))))))))..))).))))
((((.(((.(((((((((((((((((.(((...........))))))))))))))))))))..))).))))
Structure
c -A G uguu
guag acU AAGUGCUUAUAGUGCAG UAG u
|||| ||| ||||||||||||||||| ||| a
cguc uga uucacgaguauuacguc auc g
a aa - uauu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr12: 66421687-66421757 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from bta-mir-20a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature bta-miR-20a
| Accession | MIMAT0003527 |
| Description | Bos taurus bta-miR-20a mature miRNA |
| Sequence | 8 - UAAAGUGCUUAUAGUGCAGGUAG - 30 |
| Evidence |
experimental
cloned [1] |
References
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