Accession
MI0005046
Description
Bos taurus
bta-mir-423 precursor miRNA mir-423
Gene
family?
family?
RF00870;
mir-423
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Bta-mir-423 is a microRNA that has been identified as a potential biomarker and therapeutic target for bovine endometritis [PMC8433134]. It has been found to target FOXJ1 and bta-miR-149 in specific modules [PMC8433134]. In addition, several sub-networks in brown and turquoise modules have been identified, including mRNAs such as IRAK1, AKT1, STAT3, CCDC39, and ZMYND10, as well as lncRNAs and other miRNAs [PMC8433134]. Bta-mir-423 has also been found to be more abundant than its corresponding miRNA in certain cases [PMC2713767]. It is a unique miRNA found in pregnant ewes on day 14 [PMC8831238]. Bta-mir-423 is thought to target genes associated with metabolism, immune system, cell cycle, and apoptosis [PMC5699189]. Overall, bta-mir-423 shows potential for its role in bovine endometritis and may serve as a valuable biomarker for this infection.
Literature search
18 open access papers mention bta-mir-423
(61 sentences)
(61 sentences)
Sequence
113531
reads,
2314
reads per million, 78 experiments
auaaaggaaguuaggcUGAGGGGCAGAGAGCGAGACUUUucuauuuuccaaAAGCUCGGUCUGAGGCCCCUCAGUcuugcuuccuaccccgcgc
....(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).))))))).........
....(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).))))))).........
Structure
-----auaa u -AG G A cua
aggaagu aggcUGAGGGGC AGA CGAG CUUUu u
||||||| |||||||||||| ||| |||| ||||| u
uccuucg ucUGACUCCCCG UCU GCUC GAAaa u
cgcgcccca u GAG G - ccu
Annotation confidence
High
Do you think this miRNA is real?
Comments
High-throughput sequencing suggests that the dominant miRNA arises from the 5' arm of this precursor [3], in contrast to earlier studies.
Genome context
chr19: 21923268-21923361 [+]
Database links
Mature bta-miR-423-5p
| Accession | MIMAT0012537 |
| Description | Bos taurus bta-miR-423-5p mature miRNA |
| Sequence | 17 - UGAGGGGCAGAGAGCGAGACUUU - 39 |
| Evidence |
experimental
Illumina [3] |
Mature bta-miR-423-3p
| Accession | MIMAT0003831 |
| Description | Bos taurus bta-miR-423-3p mature miRNA |
| Sequence | 52 - AAGCUCGGUCUGAGGCCCCUCAGU - 75 |
| Evidence |
experimental
cloned [1], Array [2], qRT-PCR [2], Illumina [3] |
References
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