Accession
MI0005068
Description
Bos taurus
bta-mir-34c precursor miRNA mir-34
Gene
family?
family?
RF00456;
mir-34
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Bta-mir-34c is a microRNA that has been studied in various contexts [PMC7214931]. It has been found to be differentially expressed between fresh and frozen sperm [PMC7214931]. In one study, bta-mir-34c was selected for RT-qPCR validation to investigate the credibility of high-throughput sequencing [PMC6876490]. It was predicted that bta-mir-34c could bind to and regulate the expression of DDIT4 [PMC6876490]. Additionally, bta-mir-34c was confirmed to be downregulated in different studies [PMC6876490][PMC6949159][PMC9581129'>PMC6876490][PMC6949159][PMC9581129[PMC6949159][PMC9581129]. It was found to share targets with other miRNAs, such as ACAD10, PYCR1, and CLDN2 [PMC6876490]. DDIT4 was identified as a target shared by bta-mir-34c and another miRNA, bta-miR-449b [PMC6876490]. Bta-mir-34c has been implicated in cell transformation induced by BPV E5 and is involved in cancer progression and angiogenesis through the regulation of PYCR1 and DDIT4 [PMC6876490]. Technical validation of miRNA-seq data has been performed using RT-qPCR on bta-miR-100 and bta-mir-34c, which are highly expressed in bull spermatozoa [PMC9581129][PMC6731312[PMC6731312]. Bta-mir-34c is significantly downregulated in cattle-yak testis and plays a role in promoting the transition of spermatogonia from mitosis to meiosis [PMC9785434][PMC7312616[PMC7312616].
Literature search
14 open access papers mention bta-mir-34c
(80 sentences)
(80 sentences)
Sequence
373
reads,
18
reads per million, 50 experiments
agucuaguuacuAGGCAGUGUAGUUAGCUGAUUGcuaauaauaccaaucacuaaccacacggccagguaaaaagauu
.((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..)))).
.((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..)))).
Structure
a ag A A A C c a gucu uuacu GGC GUGU GUUAG UGAUUG ua u |||| ||||| ||| |||| ||||| |||||| || uaga aaugg ccg caca caauc acuaac au a u aa a g c - c a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
The mature miR-34c sequence identified by Sonstegard et al [1] has an A base at position 11 of the mature miRNA, which conflicts with the draft genome sequence that has G as shown here.
Genome context
chr15: 22282382-22282458 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from bta-mir-34c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature bta-miR-34c
| Accession | MIMAT0003854 |
| Description | Bos taurus bta-miR-34c mature miRNA |
| Sequence | 13 - AGGCAGUGUAGUUAGCUGAUUG - 34 |
| Evidence |
experimental
cloned [1], Array [2], qRT-PCR [2] |
References
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