Stem-loop hsa-mir-708

Accession

MI0005543

Symbol

HGNC: MIR708

Description

Homo sapiens hsa-mir-708 precursor miRNA mir-708

Gene
family

RF00917; mir-708

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR708 is a microRNA whose expression levels were analyzed using boxplot diagrams, leading to the exclusion of eight outliers to ensure the accuracy of the data presented [PMC6961682]. The study further demonstrated that transfection with MIR708 mimics resulted in enhanced binding of MIR708 to the Argonaute 2 (Ago2) protein, a key component in RNA-induced silencing complex (RISC) that plays a crucial role in microRNA-mediated gene silencing [PMC10067432]. Additionally, knockdown of circEZH2E2/E3 was shown to decrease its own retrieval while concurrently increasing the binding affinity of MIR708 to Ago2, suggesting a competitive relationship between circEZH2E2/E3 and MIR708 for Ago2 binding [PMC10067432].

Literature search

67 open access papers mention hsa-mir-708
(464 sentences)

Sequence

54168 reads, 475 reads per million, 121 experiments

aacugcccucAAGGAGCUUACAAUCUAGCUGGGgguaaaugacuugcacaugaacaCAACUAGACUGUGAGCUUCUAGagggcaggga
..((((((((.(((((((((((.(((((.((...((..(((.......)))..)).)).))))).))))))))))).))))))))...

Structure

-aa        A           A     C  GGg  aa   ac 
   cugcccuc AGGAGCUUACA UCUAG UG   gu  aug  u
   |||||||| ||||||||||| ||||| ||   ||  |||  u
   gacgggaG UCUUCGAGUGU AGAUC AC   ca  uac  g
agg        A           C     A  --a  ag   ac 

Annotation confidence High

Genome context

chr11: 79402022-79402109 [-]

Disease association

hsa-mir-708 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-708-5p

• Accession: MIMAT0004926
• Description: Homo sapiens hsa-miR-708-5p mature miRNA
• Sequence: 11 - AAGGAGCUUACAAUCUAGCUGGG - 33
• Evidence: experimental ; cloned [1-2]

Mature hsa-miR-708-3p

• Accession: MIMAT0004927
• Description: Homo sapiens hsa-miR-708-3p mature miRNA
• Sequence: 57 - CAACUAGACUGUGAGCUUCUAG - 78
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043