Stem-loop bta-mir-92a-1

Accession

MI0009905

Description

Bos taurus bta-mir-92a-1 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

bta-mir-92a, a microRNA, has been identified as a potential diagnostic marker in animals exposed to certain pathogens, with its expression being lower in the positive group compared to the negative group [PMC4990326]. This microRNA has been found to be highly expressed in bovine skeletal muscle and is among the most abundant miRNAs expressed across various samples [PMC4410957], [PMC4156418], [PMC6107498]. It is also considered immune-related and is consistently present among the top expressed miRNAs, suggesting a role in cattle immune response and development [PMC6940744]. Misregulation of bta-mir-92a has been observed in liver affected by LOS and its expression varies in extracellular vesicles (EVs) from embryos at different developmental stages, indicating its involvement in embryonic development [PMC6691986], [PMC7727673], [PMC8060439]. Furthermore, bta-mir-92a is implicated as a potential biomarker for pregnancy and has shown regulated expression levels during this state [PMC5325256]. Its dominant expression has also been reported in dairy cows' blood exosomes, highlighting its significance across various physiological conditions and developmental stages within cattle [PMC9445238].

Literature search

30 open access papers mention bta-mir-92a-1
(67 sentences)

Sequence

519910 reads, 5024 reads per million, 77 experiments

cuuucuacacagguugggaucgguugcaaugcuguguuucuguauggUAUUGCACUUGUCCCGGCCUGUugaguuugg
....((..((((((((((((.(((.(((((((((((......)))))))))))))).))))))))))))..)).....

Structure

-cuuu  ac            c   u           uu 
     cu  acagguugggau ggu gcaaugcugug  u
     ||  |||||||||||| ||| |||||||||||   
     ga  UGUCCGGCCCUG UCA CGUUAUgguau  c
gguuu  gu            U   -           gu 

Annotation confidence Not enough data

Genome context

chr12: 66421937-66422014 [+]

Clustered miRNAs

5 other miRNAs are < 10 kb from bta-mir-92a-1

Mature bta-miR-92a

• Accession: MIMAT0009383
• Description: Bos taurus bta-miR-92a mature miRNA
• Sequence: 48 - UAUUGCACUUGUCCCGGCCUGU - 69
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 19758457
   Characterization of bovine miRNAs by sequencing and bioinformatics analysis
   Jin W, Grant JR, Stothard P, Moore SS, Guan LL
   BMC Mol Biol (2009) 10:90


2. PubMed ID: 18945293
   Annotation of 390 bovine miRNA genes by sequence similarity with other species
   "Strozzi F, Mazza R, Malinverni R, Williams JL"
   "Anim Genet (2009) 40:125