Stem-loop hsv2-mir-H4

Accession

MI0010693

Description

Herpes Simplex Virus 2 hsv2-mir-H4 precursor miRNA

Sequence

ggggcgggaGAGUUCACUCGGCACGCAUGCacguguaaccgccaguCCGUGCUUGCCUAGCGAACUCacccguccc
((((((((.((((((.((.((((.(((((.(((((....)))..)).))))).)))).)).)))))).))))))))

Structure

        a      A  C    C     C  --   u 
ggggcggg GAGUUC CU GGCA GCAUG ac  gug a
|||||||| |||||| || |||| ||||| ||  |||  
cccugccc CUCAAG GA CCGU CGUGC ug  cgc a
        a      C  U    U     C  ac   c 

Annotation confidence Not enough data

Comments

This sequence was named miR-II in [1], but is a clear homolog of miR-H4 in HSV-1.

Genome context

Unknown

Mature hsv2-miR-H4-5p

• Accession: MIMAT0010203
• Description: Herpes Simplex Virus 2 hsv2-miR-H4-5p mature miRNA
• Sequence: 10 - GAGUUCACUCGGCACGCAUGC - 30
• Evidence: experimental ; 454 [1], Illumina [2-3]

Mature hsv2-miR-H4-3p

• Accession: MIMAT0010204
• Description: Herpes Simplex Virus 2 hsv2-miR-H4-3p mature miRNA
• Sequence: 47 - CCGUGCUUGCCUAGCGAACUC - 67
• Evidence: experimental ; 454 [1], Illumina [2-3]

References

1. PubMed ID: 20181707
   Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2
   "Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM"
   "J Virol (2010) 84:4659-4672


2. PubMed ID: 19019961
   Novel less-abundant viral microRNAs encoded by herpes simplex virus 2 latency-associated transcript and their roles in regulating ICP34.5 and ICP0 mRNAs
   "Tang S, Patel A, Krause PR"
   "J Virol (2009) 83:1433-1442


3. PubMed ID: 19889786
   Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2
   "Umbach JL, Wang K, Tang S, Krause PR, Mont EK, Cohen JI, Cullen BR"
   "J Virol (2010) 84:1189-1192