Dead hairpin entry

Stem-loop bta-mir-2904-1

Accession

MI0013080

Description

Bos taurus bta-mir-2904-1 precursor miRNA

Comment

The read data does not support this entry being a bona fide miRNA.

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

WARNING: This summary was generated by AI. Bta-mir-2904 is a microRNA (miRNA) identified among the top 10 differentially expressed miRNAs in a study, suggesting its potential biological significance [PMC9810022]. This miRNA is associated with a bacterial cluster that includes Prevotella and Bacteroides, indicating its possible role in the bovine microbiome [PMC6708143]. Bta-mir-2904 exhibits a high diversity of isomiRs, with over 100 variants identified at both the 5' and 3' ends, which may reflect its complex regulatory functions [PMC4609085]. It was also found to be highly expressed in the SA group of bulls compared to controls, suggesting its involvement in specific physiological or pathological processes [PMC6896338]. Additionally, bta-mir-2904 was prevalently expressed in low fertility (LF) bulls and identified as targeting the IL1A gene as well as DHX58, which is involved in pathogen recognition [PMC8329915], [PMC7943879]. Despite these associations with various regulatory functions, bta-mir-2904 expression was slightly downregulated when comparing low somatic cell count (SCC) to control groups [PMC8903571]. Moreover, its expression was lower during colostrum lactation compared to peak lactation [PMC5414302], and it was significantly enriched in heat stress-derived extracellular vesicles (HS-EVs) compared to control-EVs [PMC7519046].

Literature search

4 open access papers mention bta-mir-2904-1
(6 sentences)

Sequence

830768 reads, 453.0 reads per million, 321 experiments

acggcagcgccgcGGGAGCCUCGGUUGGCCUCggauagccggucccccgcCGUCCCCGCCGGCGGGCCGU
(((((..(((((((((.((..(((..((((..((....))))))..)))..)).)))).))))).)))))

Structure

     ag     -    A  CU   UU    UC  a 
acggc  cgccg cGGG GC  CGG  GGCC  gg u
|||||  ||||| |||| ||  |||  ||||  ||  
UGCCG  GCGGC GCCC UG  gcc  cugg  cc a
     -G     C    C  Cc   cc    --  g