Accession
MI0014154
Symbol
HGNC:
MIR378B
Description
Homo sapiens
hsa-mir-378b precursor miRNA
Gene family
MIPF0000168;
mir-378
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR378B is a microRNA that has been implicated in various cellular processes. It has been shown that circ_0078710 enhances the expression of PRIM2 by sponging MIR378B, and the downregulation of circ_0078710 leads to an increase in MIR378B population, resulting in the downregulation of PRIM2, which is involved in cell proliferation [PMC9774417]. MIR378B has also been found to target Usp22, which is involved in the maintenance of neural stem/progenitor cells [PMC7041117]. In a study that functionally annotated miRNAs, MIR378B was identified as one of the miRNAs involved [PMC6349826]. Another study found that ANIT downregulated MIR378B in rat liver [PMC6349826]. Additionally, MIR378B was found to be upregulated in KSHV (+) tumors and was associated with miR143-3p [PMC8242244]. In a comparison between striatum and cortex tissues, MIR378B was one of the microRNAs that showed significant association with Q values [PMC5764268]. Furthermore, it was observed that MIR378B expression was elevated in CpG-stimulated DCs with miR-378b inhibition but showed no change with miR-378 overexpression [PMC6963666]. In summary, MIR378B is a microRNA that plays a role in cell proliferation and neural stem/progenitor cell maintenance. It has been implicated in various cellular processes and its expression can be regulated by different factors.
Literature search
193 open access papers mention hsa-mir-378b
(923 sentences)
(923 sentences)
Sequence
3698
reads,
37
reads per million, 50 experiments
ggucauugagucuucaaggcuaguggaaagagcACUGGACUUGGAGGCAGAAagacc
((((.((..(((((((((.((((((.......)))))).)))))))))..)).))))
((((.((..(((((((((.((((((.......)))))).)))))))))..)).))))
Structure
a ga g ga
gguc uu gucuucaag cuagug a
|||| || ||||||||| |||||| a
ccag AA CGGAGGUUC GGUCAc g
a GA A ga
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr3: 10330229-10330285 [+]
Disease association
hsa-mir-378b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-378b
| Accession | MIMAT0014999 |
| Description | Homo sapiens hsa-miR-378b mature miRNA |
| Sequence | 34 - ACUGGACUUGGAGGCAGAA - 52 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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