Stem-loop hsa-mir-3158-1

Accession

MI0014186

Symbol

HGNC: MIR3158-1

Description

Homo sapiens hsa-mir-3158-1 precursor miRNA mir-3158

Gene
family

RF03941; mir-3158

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR3158-1 is a microRNA implicated in split-hand/foot malformation (SHFM), a congenital limb disorder [PMC5003447]. In SHFM cases, duplications often include MIR3158-1, alongside genes such as BTRC, POLL, DPCD, and FBXW4 [PMC5003447]. Specifically, MIR3158-1 is part of the shortest duplicated region identified in patients without microarray data and is consistently duplicated in the majority of SHFM cases [PMC5003447]. The duplication patterns involving MIR3158-1 vary; some patients have continuous duplications while others have two discontinuous duplications at the 10q24.31–q24.32 locus [PMC5003447'>PMC5003447]. In one instance, a patient with atypical SHFM features harbored a 241.59 kb duplication at 10q24.31-q24.32 that included MIR3158-1 [PMC5003447]. This suggests that duplications involving MIR3158-1 may contribute to a broader spectrum of phenotypes beyond classical SHFM presentations [PMC5003447].

Sequence

6644 reads, 99 reads per million, 73 experiments

auucaggccgguCCUGCAGAGAGGAAGCCCUUCugcuuacagguauuggAAGGGCUUCCUCUCUGCAGGACcggccugaau
(((((((((((((((((((((((((((((((((((((....)))...))))))))))))))))))))))))))))))))))

Structure

                                  ---   u 
auucaggccgguCCUGCAGAGAGGAAGCCCUUCu   gcu a
||||||||||||||||||||||||||||||||||   |||  
uaaguccggcCAGGACGUCUCUCCUUCGGGAAgg   ugg c
                                  uua   a 

Annotation confidence High

Genome context

chr10: 101601417-101601497 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-3158-1

Disease association

hsa-mir-3158-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-3158-3p

• Accession: MIMAT0015032
• Description: Homo sapiens hsa-miR-3158-3p mature miRNA
• Sequence: 50 - AAGGGCUUCCUCUCUGCAGGAC - 71
• Evidence: experimental ; Illumina [1-2]

Mature hsa-miR-3158-5p

• Accession: MIMAT0019211
• Description: Homo sapiens hsa-miR-3158-5p mature miRNA
• Sequence: 13 - CCUGCAGAGAGGAAGCCCUUC - 33
• Evidence: not_experimental

References

1. PubMed ID: 20300190
   Characterization of the Melanoma miRNAome by Deep Sequencing
   "Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK"
   "PLoS One (2010) 5:e9685


2. PubMed ID: 20224791
   Discovery of novel microRNAs in female reproductive tract using next generation sequencing
   Creighton CJ, Benham AL, Zhu H, Khan MF, Reid JG, Nagaraja AK, Fountain MD, Dziadek O, Han D, Ma L, Kim J, Hawkins SM, Anderson ML, Matzuk MM, Gunaratne PH
   PLoS One (2010) 5:e9637


3. PubMed ID: 21199797
   Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene
   "Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C"
   "Cancer Res (2011) 71:78-86