Accession
MI0000080
Symbol
HGNC:
MIR24-1
Description
Homo sapiens
hsa-mir-24-1 precursor miRNA
Gene family
MIPF0000041;
mir-24
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR24-1 is a microRNA that is associated with various diseases, including familial breast cancer and cervical cancer [PMC4215120]. It is located downstream of the human SLITRK1 gene and shares a high nucleotide identity with the porcine SLITRK1 recognition sequence [PMC4215120]. MIR24-1 is conserved in different species and is clustered with miR-23 and miR-27 on human chromosomes 9 and 19 [PMC4215120]. Overexpression of MIR24-1 has been shown to increase H3K27ac levels at enhancers with complementary sequences to miR-24-1 [PMC8954937]. It has been suggested that MIR24-1 may be downregulated in response to long-term potentiation (LTP), allowing the expression of a subset of linked genes [PMC3393663]. However, there seems to be no crossover between the predicted target genes of MIR34a and MIR24-1 in LTP datasets [PMC3393663]. Target prediction algorithms have identified several potential mRNA targets for MIR24-1, including FOXO1, NUMBL, and others [PMC3393663]. In addition to its role in LTP, MIR24-1 has been implicated in other biological processes such as cell proliferation and angiogenesis regulation [PMC3393663] [PMC9687337]. Knockout mice lacking both MIR24-1 and Mir24-2 have been generated using CRISPR technology [PMC8684555]. Furthermore, upregulation of MIR24-1 has been observed in response to exposure to amyloid-beta (Aβ) in nAChR-expressing cells [PMC7105468].
Literature search
347 open access papers mention hsa-mir-24-1
(2066 sentences)
(2066 sentences)
Sequence
804753
reads,
2988
reads per million, 159 experiments
cuccggUGCCUACUGAGCUGAUAUCAGUucucauuuuacacacUGGCUCAGUUCAGCAGGAACAGgag
((((.((.(((.(((((((((..(((((.............))))).))))))))).))).)).))))
((((.((.(((.(((((((((..(((((.............))))).))))))))).))).)).))))
Structure
g G A UA ucuca
cucc gU CCU CUGAGCUGA UCAGU u
|||| || ||| ||||||||| ||||| u
gagG CA GGA GACUUGACU GGUca u
A A C -C cacau
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr9: 95086021-95086088 [+]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-24-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-24-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-24-1 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-24-1 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-24-1-5p
| Accession | MIMAT0000079 |
| Description | Homo sapiens hsa-miR-24-1-5p mature miRNA |
| Sequence | 7 - UGCCUACUGAGCUGAUAUCAGU - 28 |
| Evidence |
experimental
cloned [7] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-24-3p
| Accession | MIMAT0000080 |
| Description | Homo sapiens hsa-miR-24-3p mature miRNA |
| Sequence | 44 - UGGCUCAGUUCAGCAGGAACAG - 65 |
| Evidence |
experimental
cloned [1,4-7], Northern [1], Illumina [8] |
| Database links |
|
| Predicted targets |
|
References
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