Accession
MI0000095
Symbol
HGNC:
MIR93
Description
Homo sapiens
hsa-mir-93 precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR93 is a microRNA that, intriguingly, has been observed to have upregulated expression levels despite possessing strongly hypermethylated promoters [PMC4198682]. This upregulation is notable as hypermethylation in promoter regions is typically associated with gene silencing [PMC4198682]. MIR93, along with miR191, has also been the subject of research in the context of medical health issues [PMC7430915]. Specifically, it was included in a logistic regression analysis to ascertain its potential as a predictive marker for abnormal CT findings in patients with malignant hyperthermia susceptibility (MHT) [PMC7430915]. This suggests that MIR93 may have diagnostic value and could contribute to the understanding and management of MHT [PMC7430915].
Literature search
297 open access papers mention hsa-mir-93
(1900 sentences)
(1900 sentences)
Sequence
429913
reads,
1906
reads per million, 154 experiments
cugggggcucCAAAGUGCUGUUCGUGCAGGUAGugugauuacccaaccuACUGCUGAGCUAGCACUUCCCGagcccccgg
((((((((((..((((((((((((.((((.(((.((.........)))))))))))))).)))))))...))))))))))
((((((((((..((((((((((((.((((.(((.((.........)))))))))))))).)))))))...))))))))))
Structure
-CA - U G u gau
cugggggcuc AAGUGCU GUUCG GCAG UAG gu u
|||||||||| ||||||| ||||| |||| ||| || a
ggcccccgaG UUCACGA CGAGU CGUC Auc ca c
CCC U - - - acc
Annotation confidence
High
Do you think this miRNA is real?
Comments
Mourelatos et al. identified two copies of this sequence mapping to chromosome 7, and assigned the names mir-93-7.1 and mir-93-7.2 [1]. Subsequent genome assemblies suggest the presence of only one miR-93 locus on chromosome 7. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chr7: 100093768-100093847 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-93
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-93 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-93 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-93 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-93-5p
| Accession | MIMAT0000093 |
| Description | Homo sapiens hsa-miR-93-5p mature miRNA |
| Sequence | 11 - CAAAGUGCUGUUCGUGCAGGUAG - 33 |
| Evidence |
experimental
cloned [1,3-6], Northern [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-93-3p
| Accession | MIMAT0004509 |
| Description | Homo sapiens hsa-miR-93-3p mature miRNA |
| Sequence | 50 - ACUGCUGAGCUAGCACUUCCCG - 71 |
| Evidence |
experimental
cloned [5] |
| Database links |
|
| Predicted targets |
|
References
|
