Accession
MI0000238
Symbol
HGNC:
MIR196A1
Description
Homo sapiens
hsa-mir-196a-1 precursor miRNA
Literature search
215 open access papers mention hsa-mir-196a-1
(1246 sentences)
(1246 sentences)
Sequence
150959
reads,
669
reads per million, 95 experiments
gugaauUAGGUAGUUUCAUGUUGUUGGGccuggguuucugaacaCAACAACAUUAAACCACCCGAuucac
(((((((.(((.((((.((((((((((..(.........)..).))))))))).)))).))).)))))))
(((((((.(((.((((.((((((((((..(.........)..).))))))))).)))).))).)))))))
Structure
A A C - Gc ugg
gugaauU GGU GUUU AUGUUGUUG G c g
||||||| ||| |||| ||||||||| | | u
cacuuAG CCA CAAA UACAACAAC c g u
C C U a aa ucu
Annotation confidence
High
Do you think this miRNA is real?
Comments
Lagos-Quintana et al. [1] cloned this miRNA from human osteoblast sarcoma cells. Lim et al [2] independently predicted this miRNA by computational methods using conservation with mouse and Fugu rubripes sequences [2]. Expression of the excised miR was validated in zebrafish. The sequence maps to human chromosome 17. Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr17: 48632490-48632559 [-]
Disease association
hsa-mir-196a-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-196a-1 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-196a-1 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-196a-5p
| Accession | MIMAT0000226 |
| Description | Homo sapiens hsa-miR-196a-5p mature miRNA |
| Sequence | 7 - UAGGUAGUUUCAUGUUGUUGGG - 28 |
| Evidence |
experimental
cloned [3-5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-196a-1-3p
| Accession | MIMAT0037307 |
| Description | Homo sapiens hsa-miR-196a-1-3p mature miRNA |
| Sequence | 45 - CAACAACAUUAAACCACCCGA - 65 |
| Evidence | not_experimental |
References
|
