Stem-loop sequence hsa-mir-34a

AccessionMI0000268 (change log)
Previous IDshsa-mir-34
Symbol HGNC:MIR34A
DescriptionHomo sapiens miR-34a stem-loop
Gene family MIPF0000039; mir-34
Literature search

927 open access papers mention hsa-mir-34a
(8921 sentences)

   -    -a  --    -  ug     uu        -   a          -guga  a 
5'  ggcc  gc  ugug ag  uuucu  ggcagugu cuu gcugguuguu     gc a
    ||||  ||  |||| ||  |||||  |||||||| ||| ||||||||||     ||  
3'  ccgg  ug  gcac uc  gaaga  ccgucaua gaa cgacuaacga     ug u
   c    gg  uu    g  gu     uc        u   -          aggaa  a 
Get sequence
Deep sequencing
160671 reads, 269 reads per million, 156 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Dostie et al. independently cloned this sequence in human but misnamed the sequence miR-172 (the sequence is unrelated to MIR172 from Arabidopsis) [2]. The sequence maps to human chromosome 1. Human miR-34a was previously named miR-34 here and in [1], but is renamed to clarify homology with the alternatively named mouse sequence (MI0000584). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr1: 9151668-9151777 [-]
Database links

Mature sequence hsa-miR-34a-5p

Accession MIMAT0000255
Previous IDshsa-miR-34a

22 - 


 - 43

Get sequence
Deep sequencing155952 reads, 154 experiments
Evidence experimental; cloned [2-4]
Database links
Predicted targets

Mature sequence hsa-miR-34a-3p

Accession MIMAT0004557
Previous IDshsa-miR-34a*

64 - 


 - 85

Get sequence
Deep sequencing4130 reads, 121 experiments
Evidence experimental; cloned [3]
Database links
Predicted targets


PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
PMID:12554860 "Numerous microRNPs in neuronal cells containing novel microRNAs" Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G RNA. 9:180-186(2003).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).