miRBase entry: mmu-mir-503

Stem-loop mmu-mir-503


Accession
MI0003538
Symbol
MGI: Mir503
Description
Mus musculus mmu-mir-503 precursor miRNA
Gene family
MIPF0000183; mir-503

Literature search
49 open access papers mention mmu-mir-503
(464 sentences)

Sequence

166844 reads, 1690 reads per million, 102 experiments
ugcccUAGCAGCGGGAACAGUACUGCAGugaguguuuggugcccugGAGUAUUGUUUCCACUGCCUGGgua
(((((..((((.((((((((((((.(((.(.((.......)))))).)))))))))))).))))..)))))

Structure
     UA    C            G   u a  gu 
ugccc  GCAG GGGAACAGUACU CAG g gu  u
|||||  |||| |||||||||||| ||| | ||  u
augGG  CGUC CCUUUGUUAUGA guc c cg  g
     UC    A            G   - -  ug 


Annotation confidence High
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Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].

Genome context
chrX: 53053984-53054054 [-]
Clustered miRNAs
6 other miRNAs are < 10 kb from mmu-mir-503
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-503-5p

Accession MIMAT0003188
Description Mus musculus mmu-miR-503-5p mature miRNA
Sequence 6 - UAGCAGCGGGAACAGUACUGCAG - 28
Evidence experimental
cloned [1,4-5], MPSS [2], miRAP-cloned [3], Illumina [6-7]
Database links
Predicted targets

Mature mmu-miR-503-3p

Accession MIMAT0004790
Description Mus musculus mmu-miR-503-3p mature miRNA
Sequence 47 - GAGUAUUGUUUCCACUGCCUGG - 68
Evidence experimental
cloned [5], Illumina [6-7]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16766679
    Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
    "Genes Dev (2006) 20:1732-1743

  3. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  4. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  5. PubMed ID: 16582102
    The expression profile of microRNAs in mouse embryos
    "Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M, Kato I"
    "Nucleic Acids Res (2006) 34:1765-1771

  6. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267

  7. PubMed ID: 16973894
    Mouse microRNA profiles determined with a new and sensitive cloning method
    "Takada S, Berezikov E, Yamashita Y, Lagos-Quintana M, Kloosterman WP, Enomoto M, Hatanaka H, Fujiwara S, Watanabe H, Soda M, Choi YL, Plasterk RH, Cuppen E, Mano H"
    "Nucleic Acids Res (2006) 34:e115