Accession
MI0000060
Symbol
HGNC:
MIRLET7A1
Description
Homo sapiens
hsa-let-7a-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7A1 is a microRNA gene located on chromosome 9q22.3 [PMC5356719]. It is one of the three genes expressing let-7a, along with MIRLET7A2 on 11q24.1 and MIRLET7A3 on 22q13.3 [PMC5356719]. MIRLET7A1 has been studied in the context of adenoviral shuttle vectors and priMIR expression vectors [PMC6923634]. It is targeted by several miRNAs, including members of the let-7 family, suggesting potential auto-regulation [PMC7961530]. MIRLET7A1 has also been included in targeted capture assays for detecting structural variations and copy number analysis [PMC7815088]. In the context of acute lymphoblastic leukemia (ALL), variants in MIRLET7A1 have been associated with severe hematologic toxicity arising from treatment [PMC10003057]. Specifically, variants rs12904 (MIR200C), rs3746444 (MIR499A), and rs10739971 (MIRLET7A1) have shown significant associations with hematologic toxicity in ALL patients [PMC10003057]. Furthermore, the rs10739971 variant of MIRLET7A1 has been associated with a potential protective factor against toxic hematological events in pediatric patients undergoing ALL treatment [PMC10003057]. However, no significant differences have been found for genotype and allele frequencies of several miRNAs including MIRLET7A1 between cases and controls in a specific population studied for breast cancer susceptibility [PMC4650490]. Chromosomal loss at 9q22 has also led to recurrent loss of the MIRLET7A gene family, including MIRLET7A1 [PMC7459851]. Overall, studies suggest that MIRLET7A1 plays regulatory roles in cellular processes and may have implications in cancer and therapeutic response [PMC8840188] [PMC10003057] [PMC7459851].
Literature search
1270 open access papers mention hsa-let-7a-1
(8115 sentences)
(8115 sentences)
Sequence
18681518
reads,
46519
reads per million, 159 experiments
ugggaUGAGGUAGUAGGUUGUAUAGUUuuagggucacacccaccacugggagauaaCUAUACAAUCUACUGUCUUUCcua
(((((.(((((((((((((((((((((.....(((...((((....)))).)))))))))))))))))))))))))))))
(((((.(((((((((((((((((((((.....(((...((((....)))).)))))))))))))))))))))))))))))
Structure
U uuagg aca c
uggga GAGGUAGUAGGUUGUAUAGUU guc ccca c
||||| ||||||||||||||||||||| ||| ||||
aucCU UUCUGUCAUCUAACAUAUCaa uag gggu a
- ----- --a c
Annotation confidence
High
Do you think this miRNA is real?
Comments
let-7a-3p cloned in [6] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
Genome context
chr9: 94175957-94176036 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7a-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7a-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-let-7a-5p
| Accession | MIMAT0000062 |
| Description | Homo sapiens hsa-let-7a-5p mature miRNA |
| Sequence | 6 - UGAGGUAGUAGGUUGUAUAGUU - 27 |
| Evidence |
experimental
cloned [1-3,5-8], Northern [1], Illumina [9] |
| Database links |
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| Predicted targets |
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Mature hsa-let-7a-3p
| Accession | MIMAT0004481 |
| Description | Homo sapiens hsa-let-7a-3p mature miRNA |
| Sequence | 57 - CUAUACAAUCUACUGUCUUUC - 77 |
| Evidence |
experimental
cloned [6] |
| Database links |
|
| Predicted targets |
|
References
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