miRBase entry: hsa-let-7a-5p

Mature hsa-let-7a-5p

Accession	MIMAT0000062
Description	hsa-let-7a-5p mature miRNA
Hairpins	hsa-let-7a-1 hsa-let-7a-2 hsa-let-7a-3
Sequence	UGAGGUAGUAGGUUGUAUAGUU
Evidence	experimental cloned [1-3,5-8], Northern [1], Illumina [9]
Database links
Predicted targets

QuickGo Function

QuickGO is a fast web-based browser of the Gene Ontology and Gene Ontology annotation data.

Qualifier	GO term	Evidence	Reference	Annotation Extension
acts_upstream_of	GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis	ECO:0000314 direct assay evidence used in manual assertion	PMID:30467960	occurs_in CL:0002543
enables	GO:1903231 mRNA base-pairing translational repressor activity	ECO:0000314 direct assay evidence used in manual assertion	PMID:19878981	has_input UniProtKB:P05231
enables	GO:1903231 mRNA base-pairing translational repressor activity	ECO:0000314 direct assay evidence used in manual assertion	PMID:27809873	has_input UniProtKB:P05231
enables	GO:1903231 mRNA base-pairing translational repressor activity	ECO:0000314 direct assay evidence used in manual assertion	PMID:30467960	has_input UniProtKB:Q03167
involved_in	GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway	ECO:0000314 direct assay evidence used in manual assertion	PMID:30467960	occurs_in CL:0002543
involved_in	GO:0035195 miRNA-mediated post-transcriptional gene silencing	ECO:0000314 direct assay evidence used in manual assertion	PMID:19878981	has_input UniProtKB:P05231
involved_in	GO:0035195 miRNA-mediated post-transcriptional gene silencing	ECO:0000314 direct assay evidence used in manual assertion	PMID:27809873	has_input UniProtKB:P05231
involved_in	GO:0035278 miRNA-mediated gene silencing by inhibition of translation	ECO:0000314 direct assay evidence used in manual assertion	PMID:17671087
involved_in	GO:0035279 miRNA-mediated gene silencing by mRNA destabilization	ECO:0000315 mutant phenotype evidence used in manual assertion	PMID:17671087
involved_in	GO:0035279 miRNA-mediated gene silencing by mRNA destabilization	ECO:0000314 direct assay evidence used in manual assertion	PMID:30467960	has_input UniProtKB:Q03167
involved_in	GO:0070104 negative regulation of interleukin-6-mediated signaling pathway	ECO:0000314 direct assay evidence used in manual assertion	PMID:19878981
located_in	GO:0005615 extracellular space	ECO:0007005 high throughput direct assay evidence used in manual assertion	PMID:18766170	part_of UBERON:0001969
located_in	GO:0005615 extracellular space	ECO:0007005 high throughput direct assay evidence used in manual assertion	PMID:26646931	part_of UBERON:0001969
located_in	GO:0070062 extracellular exosome	ECO:0000314 direct assay evidence used in manual assertion	PMID:31926946	produced_by CL:0000235
located_in	GO:1903561 extracellular vesicle	ECO:0007005 high throughput direct assay evidence used in manual assertion	PMID:28798470	produced_by CL:0000182

StarBase

MicroRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data.

Target Gene ID	Target Gene Name	Number of supporting experiments	Number of target-predicting programs	Maximum number of target sites	Chromosome	Target-predicting region start	Target-predicting region end	Strand

miR2Disease

A manually curated database, aimed at providing a comprehensive resource of miRNA deregulation in various human diseases.

Click here for more information and to obtain references for the studies.

Disease	Differential expression	Experiment	Year	Study