miRBase entry: hsa-let-7a-2

Stem-loop hsa-let-7a-2

Homo sapiens hsa-let-7a-2 precursor miRNA
Gene family
MIPF0000002; let-7

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIRLET7A2 is a gene that is overexpressed in the PP adipose tissue of patients with prostate cancer (EPCa) [PMC3523039]. It is also overexpressed in the PP adipose tissue of obese/overweight (OB/OW) subjects with cancer compared to benign prostatic hyperplasia (BPH) [PMC3523039]. The MIRLET7A2 locus is located within a region that expresses several non-coding RNAs and is flanked by BORIS and CTCF binding sites [PMC5650274]. The MIRLET7A2 gene can be knocked out using sgRNAs and DICER plasmids [PMC9134915]. Chromosomal loss at 9q22 causes loss of the MIRLET7A gene family, including MIRLET7A2 [PMC7459851]. Methylation levels of CG dinucleotides in the promoter region of MIRLET7A2 can influence its expression [PMC9847511]. MIRLET7A2, along with other miRNA encoding genes, has low expression in murine eyes and is not expressed in ARPE-19 cell lines [PMC9847511]. The custom gene panel for mutation profiling includes MIRLET7A2 for pediatric cancers [PMC7341754]. Certain miRNAs, including MIRLET7A2, are suppressed upon differentiation [PMC4168020]. Deletion rates for MIRLET7A3 are higher than those for MIRLET7A2 and other genes within the let-7a cluster in certain cases [PMC5400605]. No significant differences were found for genotype and allele frequencies of SNPs located near miRNAs including MIRLET7A1 and MIRLET7A2 [PMC4650490].

Literature search
1268 open access papers mention hsa-let-7a-2
(7971 sentences)


18670398 reads, 46265 reads per million, 153 experiments

   uU   G   U             uagaauuac   aa 
agg  GAG UAG AGGUUGUAUAGUU         auc  g
|||  ||| ||| |||||||||||||         |||   
uCC  UUC AUC UCCGACAUGUCaa         uag  g
   -U   G   C             ---------   ag 

Annotation confidence High
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Genome context
chr11: 122146522-122146593 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7a-2
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-let-7a-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-let-7a-5p

Accession MIMAT0000062
Description Homo sapiens hsa-let-7a-5p mature miRNA
Evidence experimental
cloned [1-3,5-8], Northern [1], Illumina [9]
Database links
Predicted targets

Mature hsa-let-7a-2-3p

Accession MIMAT0010195
Description Homo sapiens hsa-let-7a-2-3p mature miRNA
Evidence experimental
qRT-PCR [9]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  3. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  4. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  5. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  6. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  7. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  8. PubMed ID: 17989717
    Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
    "Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A"
    "Leukemia (2008) 22:330-338

  9. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  10. PubMed ID: 19015728
    MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cells
    Tzur G, Levy A, Meiri E, Barad O, Spector Y, Bentwich Z, Mizrahi L, Katzenellenbogen M, Ben-Shushan E, Reubinoff BE, Galun E
    PLoS One (2008) 3:e3726