Accession
MI0000061
Symbol
HGNC:
MIRLET7A2
Description
Homo sapiens
hsa-let-7a-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7A2 is a microRNA gene that has been observed to be overexpressed in the periprostatic (PP) adipose tissue of patients with endocrine prostate cancer (EPCa), both in overall analyses and specifically within lean and obese/overweight (OB/OW) groups [PMC3523039]. This overexpression is also consistent in OB/OW subjects when compared to benign prostatic hyperplasia (BPH) [PMC3523039]. The gene is situated within a region that expresses several non-coding RNAs and is flanked by binding sites for the regulatory proteins BORIS and CTCF [PMC5650274]. MIRLET7A2 has been included in targeted capture for mutation profiling due to its relevance in cancer research [PMC7815088]. Additionally, MIRLET7A2's promoter region has been reported to show a significant decrease in methylation, which could influence its expression levels [PMC9847511]. Despite its noted expression changes, no significant differences were found for genotype and allele frequencies of MIRLET7A2 between cases and controls in a genotyping study of breast cancer patients [PMC4650490]. The gene's relevance is further highlighted by its inclusion in custom gene panels designed for mutation profiling of pediatric cancers [PMC7341754].
Literature search
1268 open access papers mention hsa-let-7a-2
(7971 sentences)
(7971 sentences)
Sequence
18670398
reads,
37673
reads per million, 153 experiments
agguUGAGGUAGUAGGUUGUAUAGUUuagaauuacaucaagggagauaaCUGUACAGCCUCCUAGCUUUCCu
(((..(((.(((.(((((((((((((.........(((......)))))))))))))))).))).))).)))
(((..(((.(((.(((((((((((((.........(((......)))))))))))))))).))).))).)))
Structure
uU G U uagaauuac aa agg GAG UAG AGGUUGUAUAGUU auc g ||| ||| ||| ||||||||||||| ||| uCC UUC AUC UCCGACAUGUCaa uag g -U G C --------- ag
Annotation confidence
High
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Genome context
chr11: 122146522-122146593 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7a-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7a-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-let-7a-5p
| Accession | MIMAT0000062 |
| Description | Homo sapiens hsa-let-7a-5p mature miRNA |
| Sequence | 5 - UGAGGUAGUAGGUUGUAUAGUU - 26 |
| Evidence |
experimental
cloned [1-3,5-8], Northern [1], Illumina [9] |
| Database links |
|
| Predicted targets |
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Mature hsa-let-7a-2-3p
| Accession | MIMAT0010195 |
| Description | Homo sapiens hsa-let-7a-2-3p mature miRNA |
| Sequence | 50 - CUGUACAGCCUCCUAGCUUUCC - 71 |
| Evidence |
experimental
qRT-PCR [9] |
| Database links |
|
| Predicted targets |
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References
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