Accession
MI0000062
Symbol
HGNC:
MIRLET7A3
Description
Homo sapiens
hsa-let-7a-3 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7A3 is a gene that belongs to the MIRLET7A gene family, which also includes MIRLET7A1 and MIRLET7A2 [PMC7459851]. It is located at 22q12.31 within the MIRLET7BHG gene [PMC6353855]. The hypermethylation of the MIRLET7A3 gene has been reported in various cancers, including acute myeloid leukemia, ovarian cancer, and breast cancer [PMC6353855]. In hepatocellular carcinoma (HCC), the CpG island in the MIRLET7A3 gene is hypermethylated compared to healthy liver tissue [PMC6353855]. The deletion of the 22q13.31 region where MIRLET7A3 maps is frequently observed in ovarian tumors [PMC5400605]. In breast carcinomas, hypermethylation of the super-enhancer region associated with MIRLET7B and MIRLET7A3 leads to their transcriptional silencing [PMC4728783]. The array Comparative Genomic Hybridization study identified three genes expressing let-7a: MIRLET7A1 on 9q22.3, MIRLET7A2 on 11q24.1, and MIRLET7A3 on 22q13.3 [PMC5356719]. A custom gene panel was designed to include microRNA genes such as MIR100, MIRETLETA1-2-3-B-C-D-E-F-G for mutation profiling of pediatric cancers [PMC7341754]. Mutations in IL6 and LIN28a genes were also investigated but no mutations were found in these genes associated with IL-6 regulatory pathway [PMC3601972].
Literature search
1266 open access papers mention hsa-let-7a-3
(7978 sentences)
(7978 sentences)
Sequence
18712120
reads,
46706
reads per million, 153 experiments
gggUGAGGUAGUAGGUUGUAUAGUUuggggcucugcccugcuaugggauaaCUAUACAAUCUACUGUCUUUCcu
(((.(((((((((((((((((((((((((((...)))))).........))))))))))))))))))))).)))
(((.(((((((((((((((((((((((((((...)))))).........))))))))))))))))))))).)))
Structure
U --------- u ggg GAGGUAGUAGGUUGUAUAGUU uggggc ||| ||||||||||||||||||||| |||||| c ucC UUCUGUCAUCUAACAUAUCaa gucccg U uaggguauc u
Annotation confidence
High
Do you think this miRNA is real?
Comments
let-7a-3p cloned in [6] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
Genome context
chr22: 46112749-46112822 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7a-3
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7a-3 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-let-7a-5p
| Accession | MIMAT0000062 |
| Description | Homo sapiens hsa-let-7a-5p mature miRNA |
| Sequence | 4 - UGAGGUAGUAGGUUGUAUAGUU - 25 |
| Evidence |
experimental
cloned [1-3,5-8], Northern [1], Illumina [9] |
| Database links |
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| Predicted targets |
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Mature hsa-let-7a-3p
| Accession | MIMAT0004481 |
| Description | Homo sapiens hsa-let-7a-3p mature miRNA |
| Sequence | 52 - CUAUACAAUCUACUGUCUUUC - 72 |
| Evidence |
experimental
cloned [6] |
| Database links |
|
| Predicted targets |
|
References
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