miRBase entry: hsa-mir-17

Stem-loop hsa-mir-17

Homo sapiens hsa-mir-17 precursor miRNA
Gene family
MIPF0000001; mir-17

Caution, this is an AI generated summary based on literature. This may have errors. ?

Finally, grapefruit-derived nanovectors have been successfully used to deliver therapeutic MIR17 to the brain [PMC8067521]. Both double-knockdown lines, MIR17,18 and MIR17,g18-1, exhibited significant reductions in shoot surface area compared to the wild type and single mutants [PMC8528425]. This shoot growth impairment was not observed in any of the single mutants [PMC8528425]. The levels of STAT3, a protein involved in various cellular processes, are primarily regulated by MIR17, miR20a, miR19a, BRCA1, NF-KB1, ETS1, and ATF1 [PMC8627999].

Literature search
756 open access papers mention hsa-mir-17
(4318 sentences)


1979064 reads, 12840 reads per million, 159 experiments

    ga       -CA        A  G     G   -  au 
guca  auaaugu   AAGUGCUU CA UGCAG UAG ug  a
||||  |||||||   |||||||| || ||||| ||| ||  u
cagu  uauuacG   UUCACGGA GU ACGUC Auc ac  g
    gg       AUG        A  G     -   u  gu 

Annotation confidence High
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Genome context
chr13: 91350605-91350688 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-17
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-17 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-17 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-17 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-17-5p

Accession MIMAT0000070
Description Homo sapiens hsa-miR-17-5p mature miRNA
Evidence experimental
cloned [2,5-8], Northern [4]
Database links
Predicted targets

Mature hsa-miR-17-3p

Accession MIMAT0000071
Description Homo sapiens hsa-miR-17-3p mature miRNA
Evidence experimental
cloned [1,5,7-8], Northern [1]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  3. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  4. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  5. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  6. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  7. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728

  8. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854