Stem-loop hsa-mir-93

Accession

MI0000095

Symbol

HGNC: MIR93

Description

Homo sapiens hsa-mir-93 precursor miRNA mir-17

Gene
family

RF00051; mir-17

Literature search

297 open access papers mention hsa-mir-93
(1900 sentences)

Sequence

429913 reads, 1906 reads per million, 154 experiments

cugggggcucCAAAGUGCUGUUCGUGCAGGUAGugugauuacccaaccuACUGCUGAGCUAGCACUUCCCGagcccccgg
((((((((((..((((((((((((.((((.(((.((.........)))))))))))))).)))))))...))))))))))

Structure

          -CA       -     U    G   u  gau 
cugggggcuc   AAGUGCU GUUCG GCAG UAG gu   u
||||||||||   ||||||| ||||| |||| ||| ||   a
ggcccccgaG   UUCACGA CGAGU CGUC Auc ca   c
          CCC       U     -    -   -  acc 

Annotation confidence High

Comments

Mourelatos et al. identified two copies of this sequence mapping to chromosome 7, and assigned the names mir-93-7.1 and mir-93-7.2 [1]. Subsequent genome assemblies suggest the presence of only one miR-93 locus on chromosome 7. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr7: 100093768-100093847 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-93

Disease association

hsa-mir-93 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-93 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-93 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-93-5p

• Accession: MIMAT0000093
• Description: Homo sapiens hsa-miR-93-5p mature miRNA
• Sequence: 11 - CAAAGUGCUGUUCGUGCAGGUAG - 33
• Evidence: experimental ; cloned [1,3-6], Northern [4]

Mature hsa-miR-93-3p

• Accession: MIMAT0004509
• Description: Homo sapiens hsa-miR-93-3p mature miRNA
• Sequence: 50 - ACUGCUGAGCUAGCACUUCCCG - 71
• Evidence: experimental ; cloned [5]

References

1. PubMed ID: 12554860
   Numerous microRNPs in neuronal cells containing novel microRNAs
   "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
   "RNA (2003) 9:180-186


2. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


3. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


4. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


5. PubMed ID: 11914277
   miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
   "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
   "Genes Dev (2002) 16:720-728


6. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854