Stem-loop hsa-mir-103a-2

Accession

MI0000108

Symbol

HGNC: MIR103A2

Description

Homo sapiens hsa-mir-103a-2 precursor miRNA mir-103

Gene
family

RF00129; mir-103

Literature search

258 open access papers mention hsa-mir-103a-2
(975 sentences)

Sequence

5004011 reads, 15897 reads per million, 156 experiments

uugugcuuucAGCUUCUUUACAGUGCUGCCUUGuagcauucaggucaAGCAGCAUUGUACAGGGCUAUGAaagaacca
..((.(((((((((.((.(((((((((((.(((.(.(.....).))))))))))))))).)))))..)))))).))..

Structure

uu  g      --   U  U           C   u g a 
  gu cuuucA  GCU CU UACAGUGCUGC UUG a c u
  || ||||||  ||| || ||||||||||| ||| | | u
  ca gaaAGU  CGG GA AUGUUACGACG Aac u g c
ac  a      AU   -  C           -   - g a 

Annotation confidence High

Comments

This sequence was localised to chromosome 20 and named mir-103-20 in reference [1].

Genome context

chr20: 3917494-3917571 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-103a-2

Disease association

hsa-mir-103a-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-103a-2-5p

• Accession: MIMAT0009196
• Description: Homo sapiens hsa-miR-103a-2-5p mature miRNA
• Sequence: 11 - AGCUUCUUUACAGUGCUGCCUUG - 33
• Evidence: experimental ; 454 [5]

Mature hsa-miR-103a-3p

• Accession: MIMAT0000101
• Description: Homo sapiens hsa-miR-103a-3p mature miRNA
• Sequence: 48 - AGCAGCAUUGUACAGGGCUAUGA - 70
• Evidence: experimental ; cloned [1-4], Northern [2], Illumina [5]

References

1. PubMed ID: 15183728
   Human embryonic stem cells express a unique set of microRNAs
   "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
   "Dev Biol (2004) 270:488-498


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 20158877
   Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
   Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
   BMC Genomics (2010) 11:S6


5. PubMed ID: 11914277
   miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
   "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
   "Genes Dev (2002) 16:720-728


6. PubMed ID: 19144710
   Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
   "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
   "J Virol (2009) 83:3333-3341