Accession
MI0000115
Symbol
HGNC:
MIR16-2
Description
Homo sapiens
hsa-mir-16-2 precursor miRNA mir-15
Gene
family?
family?
RF00455;
mir-15
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
To investigate the molecular mechanism of how R-2HG/ERĪ± decreases miR16-5p expression at the transcriptional level, Zhang et al. (2021) applied the Ensembl website with JASPAR database approaches to search for potential estrogen response elements (EREs) on the 3-kb region of miR16-1 and MIR16-2 promoters [PMC8479483]. Among the top 10 miRNAs with the highest absolute amount, MIR16-2 was identified [PMC8010072]. MIR16-2 is located on the intronic region of Structural Maintenance of Chromosomes 4 (SMC4) on chromosome 3 [PMC9553902]. Furthermore, CHORDC1 and MIR16-2 were found to be upregulated at D15 with fold changes of 4.54 [PMC8407676]. The expression levels of MIR16-2 were observed to be high during the S phase and gradually decrease during G2M and G1 phases in fibroblasts [PMC8713755]. In lung cancer, overexpression of BCL2 was associated with underexpression of MIR15A, MIR16-1, and MIR16-2 [PMC2683874]. Similarly, in kidney tumors, overexpression of DFFB, HTATIP, and RELA was related to underexpression of MIR124A-1, MIR124A-2, and MIR124A-3 [PMC2683874].
Literature search
682 open access papers mention hsa-mir-16-2
(3207 sentences)
(3207 sentences)
Sequence
2322800
reads,
10575
reads per million, 146 experiments
guuccacucUAGCAGCACGUAAAUAUUGGCGuagugaaauauauauuaaacaCCAAUAUUACUGUGCUGCUUUAgugugac
(((.((((..(((((((((..((((((((.((.................)).))))))))..)))))))))..)))).)))
(((.((((..(((((((((..((((((((.((.................)).))))))))..)))))))))..)))).)))
Structure
c cU UA C agugaaa guu cacu AGCAGCACG AAUAUUGG Gu u ||| |||| ||||||||| |||||||| || a cag gugA UCGUCGUGU UUAUAACC ca u u UU CA a aauuaua
Annotation confidence
High
Do you think this miRNA is real?
Comments
This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references [1] and [2].
Genome context
chr3: 160404745-160404825 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-16-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-16-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-16-5p
| Accession | MIMAT0000069 |
| Description | Homo sapiens hsa-miR-16-5p mature miRNA |
| Sequence | 10 - UAGCAGCACGUAAAUAUUGGCG - 31 |
| Evidence |
experimental
cloned [1,3-4,6-8], Northern [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-16-2-3p
| Accession | MIMAT0004518 |
| Description | Homo sapiens hsa-miR-16-2-3p mature miRNA |
| Sequence | 53 - CCAAUAUUACUGUGCUGCUUUA - 74 |
| Evidence |
experimental
cloned [7] |
| Database links |
|
| Predicted targets |
|
References
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