miRBase entry: hsa-mir-16-2

Stem-loop hsa-mir-16-2

Homo sapiens hsa-mir-16-2 precursor miRNA
Gene family
MIPF0000006; mir-15

Caution, this is an AI generated summary based on literature. This may have errors. ?

To investigate the molecular mechanism of how R-2HG/ERĪ± decreases miR16-5p expression at the transcriptional level, Zhang et al. (2021) applied the Ensembl website with JASPAR database approaches to search for potential estrogen response elements (EREs) on the 3-kb region of miR16-1 and MIR16-2 promoters [PMC8479483]. Among the top 10 miRNAs with the highest absolute amount, MIR16-2 was identified [PMC8010072]. MIR16-2 is located on the intronic region of Structural Maintenance of Chromosomes 4 (SMC4) on chromosome 3 [PMC9553902]. Furthermore, CHORDC1 and MIR16-2 were found to be upregulated at D15 with fold changes of 4.54 [PMC8407676]. The expression levels of MIR16-2 were observed to be high during the S phase and gradually decrease during G2M and G1 phases in fibroblasts [PMC8713755]. In lung cancer, overexpression of BCL2 was associated with underexpression of MIR15A, MIR16-1, and MIR16-2 [PMC2683874]. Similarly, in kidney tumors, overexpression of DFFB, HTATIP, and RELA was related to underexpression of MIR124A-1, MIR124A-2, and MIR124A-3 [PMC2683874].

Literature search
682 open access papers mention hsa-mir-16-2
(3207 sentences)


2322800 reads, 10575 reads per million, 146 experiments

   c    cU         UA        C  agugaaa 
guu cacu  AGCAGCACG  AAUAUUGG Gu       u
||| ||||  |||||||||  |||||||| ||       a
cag gugA  UCGUCGUGU  UUAUAACC ca       u
   u    UU         CA        a  aauuaua 

Annotation confidence High
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This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references [1] and [2].

Genome context
chr3: 160404745-160404825 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-16-2
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-16-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-16-5p

Accession MIMAT0000069
Description Homo sapiens hsa-miR-16-5p mature miRNA
Evidence experimental
cloned [1,3-4,6-8], Northern [3]
Database links
Predicted targets

Mature hsa-miR-16-2-3p

Accession MIMAT0004518
Description Homo sapiens hsa-miR-16-2-3p mature miRNA
Evidence experimental
cloned [7]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  3. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  4. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  5. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  6. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  7. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728

  8. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540