miRBase entry: dme-mir-10

Stem-loop dme-mir-10


Accession
MI0000130
Description
Drosophila melanogaster dme-mir-10 precursor miRNA

Literature search
19 open access papers mention dme-mir-10
(178 sentences)

Sequence

759116 reads, 6448 reads per million, 49 experiments
ccacgucuACCCUGUAGAUCCGAAUUUGUUuuauacuagcuuuaaggaCAAAUUCGGUUCUAGAGAGGUUUgugugg
(((((...(((((.((((.(((((((((((((............))))))))))))).)))).)).)))...)))))

Structure
     ucu   -  G    U             auacu 
ccacg   ACC CU UAGA CCGAAUUUGUUuu     a
|||||   ||| || |||| |||||||||||||      
ggugu   UGG GA AUCU GGCUUAAACagga     g
     gUU   A  G    U             auuuc 


Annotation confidence High
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Comments
The first cloning experiments identified the mature miR-10 from the 5' arm of the D. melanogaster precursor [1,3]. High-throughput sequencing later showed that the sequence from the 3' arm dominates [4-5].

Genome context
chr3R: 6809506-6809582 [-]

Database links

Mature dme-miR-10-5p

Accession MIMAT0000115
Description Drosophila melanogaster dme-miR-10-5p mature miRNA
Sequence 9 - ACCCUGUAGAUCCGAAUUUGUU - 30
Evidence experimental
cloned [1,3], Northern [1-3], 454 [4-5], Illumina [5]
Database links

Mature dme-miR-10-3p

Accession MIMAT0012531
Description Drosophila melanogaster dme-miR-10-3p mature miRNA
Sequence 49 - CAAAUUCGGUUCUAGAGAGGUUU - 71
Evidence experimental
cloned [1,3], Northern [1-3], 454 [4-5], Illumina [5]
Database links

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 12812784
    Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    "Sempere LF, Sokol NS, Dubrovsky EB, Berger EM, Ambros V"
    "Dev Biol (2003) 259:9-18

  3. PubMed ID: 12919683
    The small RNA profile during Drosophila melanogaster development
    "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
    "Dev Cell (2003) 5:337-350

  4. PubMed ID: 17989254
    Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
    "Genome Res (2007) 17:1850-1864

  5. PubMed ID: 17989255
    Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
    "Genome Res (2007) 17:1865-1879