miRBase entry: hsa-mir-199a-1

Stem-loop hsa-mir-199a-1

Homo sapiens hsa-mir-199a-1 precursor miRNA
Gene family
MIPF0000040; mir-199

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR199A1 is a microRNA that has been studied in various contexts. In a study using the miR-VILO kit, it was found that MIR199A1 was significantly upregulated following 48 hours of Bb infection [PMC5279786]. MIR199A1 is one of the microRNAs validated in the GSE94462 dataset [PMC9922242]. It is also available for purchase from OriGene [PMC7228945]. MIR199A1 is located on chromosome 19 and shares a domain with miR21 and miR155 genes, suggesting functional partnerships [PMC9962339]. In hypospadias, MIR199A1 was identified as one of the potentially associated non-coding RNAs [PMC9834259]. The human genome has two genes encoding mature miR-199a-3p, with MIR199A1 on chromosome 19 and MIR199A2 on chromosome 1 [PMC9177676]. Differential expression of non-coding RNAs, including MIR199A1, may play a role in tumor differentiation [PMC7433108]. Overall, these studies highlight the significance of MIR199A1 in various biological processes and diseases.

Literature search
378 open access papers mention hsa-mir-199a-1
(2681 sentences)


3282217 reads, 10221 reads per million, 150 experiments

   aaC       U        C   --U  -g   g 
gcc   CCAGUGU CAGACUAC UGU   Ca  gag  
|||   ||||||| |||||||| |||   ||  ||| c
cgg   GGUUACA GUCUGAUG ACA   gu  cuc  
   AUU       C        -   ugu  aa   u 

Annotation confidence High
Do you think this miRNA is real?
Lagos-Quintana et al. [1] cloned miR-199 from human osteoblast sarcoma cells. They also reported identification of a miRNA from the opposite arm in mouse cells. This sequence was named miR-199-s and the sequence from the 3' arm of the homologous mouse precursor miR-199-as. Lim et al. [2] independently predicted this miRNA computationally using conservation with mouse and Fugu rubripes sequences [2]. Expression of the miR excised from the 5' arm was validated in zebrafish, and the ends mapped by cloning. The excised miR sequences are renamed miR-199a (to avoid confusion with the subsequently identified miR-199b (MIR:MI0000282)) and miR-199a* (from the 3' arm) here. The two putative hairpin precursors in human map to chromosome 19 (mir-199a-1, MIR:MI0000242) and chromosome 1 (mir-199a-2, MIR:MI0000281). Landgraf et al. show that both mature products are expressed, prompting the renaming to miR-199a-5p and miR-199a-3p [4].

Genome context
chr19: 10817426-10817496 [-]

Disease association
hsa-mir-199a-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-199a-5p

Accession MIMAT0000231
Description Homo sapiens hsa-miR-199a-5p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets

Mature hsa-miR-199a-3p

Accession MIMAT0000232
Description Homo sapiens hsa-miR-199a-3p mature miRNA
Evidence experimental
cloned [4], Illumina [5]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  4. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  5. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179