Accession
MI0000268
Symbol
HGNC:
MIR34A
Description
Homo sapiens
hsa-mir-34a precursor miRNA mir-34
Gene
family?
family?
RF00456;
mir-34
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR34A is found to be downregulated in gastric cancer cell lines, such as BGC-823, compared to normal gastric epithelium cell lines [PMC4650715]. It has been suggested that MYCN downregulates MIR34A, similar to the action of c-Myc in colon carcinoma cells [PMC6048510]. MIR34A upregulation in T cells may explain the increased induction and activated state of T cells [PMC5351619]. The expression patterns of mature MIR34A differ from pri-MIR34A in METTL3-knockdown and METTL3-overexpressing cells [PMC7347714]. MIR34A is needed to repress Lef-1 post-transcriptionally along with miR-223 [PMC6282069]. The head-to-head orientation of the MIR34A HG and lncTAM34a allows for direct binding and targeting by sequence complementarity between the RNA and promoter DNA [PMC6030072]. Disruption of both TP53 and MIR34A is associated with poor survival in cancer patients [PMC4039115]. MIR34A negatively regulates dendrite outgrowth, while miR-124 positively regulates axonal and dendritic branching [PMC5928558]. The regulation of MHC-I by MIR34A in hippocampal neurons still needs further investigation [PMC7655649]. Co-administration of MIR34A with Dox inhibits invasion and migration in breast cancer cells [PMC8463267]..\
Literature search
927 open access papers mention hsa-mir-34a
(9143 sentences)
(9143 sentences)
Sequence
47919
reads,
442
reads per million, 147 experiments
ggccagcugugaguguuucuuUGGCAGUGUCUUAGCUGGUUGUugugagcaauaguaaggaagCAAUCAGCAAGUAUACUGCCCUagaagugcugcacguuguggggccc
((((.(((((((((((((((..(((((((((((.((((((((((....((....)).....))))))))))))).))))))))..))))))))).))))..))..)))).
((((.(((((((((((((((..(((((((((((.((((((((((....((....)).....))))))))))))).))))))))..))))))))).))))..))..)))).
Structure
- -a -- - uU - A -guga a ggcc gc ugug aguguuucu GGCAGUGU CUU GCUGGUUGUu gc a |||| || |||| ||||||||| |||||||| ||| |||||||||| || ccgg ug gcac ucgugaaga CCGUCAUA GAA CGACUAACga ug u c gg uu g UC U - aggaa a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Dostie et al. independently cloned this sequence in human but misnamed the sequence miR-172 (the sequence is unrelated to MIR172 from Arabidopsis) [2]. The sequence maps to human chromosome 1. Human miR-34a was previously named miR-34 here and in [1], but is renamed to clarify homology with the alternatively named mouse sequence (MIR:MI0000584). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr1: 9151668-9151777 [-]
Disease association
hsa-mir-34a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-34a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-34a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-34a-5p
| Accession | MIMAT0000255 |
| Description | Homo sapiens hsa-miR-34a-5p mature miRNA |
| Sequence | 22 - UGGCAGUGUCUUAGCUGGUUGU - 43 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-34a-3p
| Accession | MIMAT0004557 |
| Description | Homo sapiens hsa-miR-34a-3p mature miRNA |
| Sequence | 64 - CAAUCAGCAAGUAUACUGCCCU - 85 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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