Accession
MI0000279
Symbol
HGNC:
MIR196A2
Description
Homo sapiens
hsa-mir-196a-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR196A2 is a non-coding RNA gene that has been implicated in various clinical symptoms [PMC5363543]. The rs11614913 C allele in MIR196A2 has been found to be associated with infertility and increased pain severity [PMC5363543]. In a study, BACs on three different chromosomes were identified, including MIR196A2, which is associated with lower limb development [PMC4041413]. However, SNP rs7372209 in MIR26A1 was not found to be associated with any clinical symptoms [PMC5363543].
Literature search
227 open access papers mention hsa-mir-196a-2
(1268 sentences)
(1268 sentences)
Sequence
156910
reads,
1227
reads per million, 95 experiments
ugcucgcucagcugaucuguggcuUAGGUAGUUUCAUGUUGUUGGGauugaguuuugaacuCGGCAACAAGAAACUGCCUGAGuuacaucagucgguuuucgucgagggc
..(((((..(((((((.((((((((((((((((((.((((((((((.((........)))))))))))).))))))))))))))))))...)))))))...).))))...
..(((((..(((((((.((((((((((((((((((.((((((((((.((........)))))))))))).))))))))))))))))))...)))))))...).))))...
Structure
-ug - -uc --c A a gag cucg c agcugau uguggcuUAGGUAGUUUC UGUUGUUGGG uu u |||| | ||||||| |||||||||||||||||| |||||||||| || gagc g uuggcug acauuGAGUCCGUCAAAG ACAACGGCuc aa u cgg u cuu acu A - guu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. miR-196a was later validated in human [3,4]. Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr12: 53991738-53991847 [+]
Disease association
hsa-mir-196a-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-196a-5p
| Accession | MIMAT0000226 |
| Description | Homo sapiens hsa-miR-196a-5p mature miRNA |
| Sequence | 25 - UAGGUAGUUUCAUGUUGUUGGG - 46 |
| Evidence |
experimental
cloned [3-5] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-196a-3p
| Accession | MIMAT0004562 |
| Description | Homo sapiens hsa-miR-196a-3p mature miRNA |
| Sequence | 62 - CGGCAACAAGAAACUGCCUGAG - 83 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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