miRBase entry: hsa-mir-196a-2

Stem-loop hsa-mir-196a-2

Homo sapiens hsa-mir-196a-2 precursor miRNA
Gene family
MIPF0000031; mir-196

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR196A2 is a non-coding RNA gene that has been implicated in various clinical symptoms [PMC5363543]. The rs11614913 C allele in MIR196A2 has been found to be associated with infertility and increased pain severity [PMC5363543]. In a study, BACs on three different chromosomes were identified, including MIR196A2, which is associated with lower limb development [PMC4041413]. However, SNP rs7372209 in MIR26A1 was not found to be associated with any clinical symptoms [PMC5363543].

Literature search
227 open access papers mention hsa-mir-196a-2
(1268 sentences)


156910 reads, 1227 reads per million, 95 experiments

-ug    - -uc       --c                  A          a  gag 
   cucg c   agcugau   uguggcuUAGGUAGUUUC UGUUGUUGGG uu   u
   |||| |   |||||||   |||||||||||||||||| |||||||||| ||    
   gagc g   uuggcug   acauuGAGUCCGUCAAAG ACAACGGCuc aa   u
cgg    u cuu       acu                  A          -  guu 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. miR-196a was later validated in human [3,4]. Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr12: 53991738-53991847 [+]

Disease association
hsa-mir-196a-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-196a-5p

Accession MIMAT0000226
Description Homo sapiens hsa-miR-196a-5p mature miRNA
Evidence experimental
cloned [3-5]
Database links
Predicted targets

Mature hsa-miR-196a-3p

Accession MIMAT0004562
Description Homo sapiens hsa-miR-196a-3p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  4. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179

  5. PubMed ID: 15105502
    MicroRNA-directed cleavage of HOXB8 mRNA
    "Yekta S, Shih IH, Bartel DP"
    "Science (2004) 304:594-596