miRBase entry: hsa-mir-199a-2

Stem-loop hsa-mir-199a-2

Homo sapiens hsa-mir-199a-2 precursor miRNA
Gene family
MIPF0000040; mir-199

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR199A2 is a gene located on chromosome 1 that encodes for a microRNA [PMC3281082]. It is one of the MIRs that regulate the expression of anti-apoptotic genes and is frequently found in regions altered in cancer [PMC2683874]. The promoter region of MIR199A2 has been analyzed and cloned into a vector for further study [PMC3668635]. It has been found to be consistently upregulated or downregulated in different passages of cells [PMC6694630]. MIR199A2 has also been found to be differentially methylated in a pilot study [PMC4446486]. It is located within the intron region of the DNM3OS gene [PMC8326843]. The expression of MIR199A2 has been inversely correlated with miR23B and its differential regulation at the transcriptional level has been suggested in ovarian cancer cells [PMC5814174] [PMC2889129]. In Alzheimer's disease, MIR199A2 has been found to be upregulated, along with other miRNAs such as MIR129-2, MIR219A1, and MIR92A1, while other miRNAs like MIR1296 and MIR431 are downregulated [PMC7564652]. The dysregulation of these miRNAs may play a role in AD pathology. In addition, it has been identified as one of the top 10 miRNAs with the highest absolute amount in certain contexts [PMC8010072]

Literature search
379 open access papers mention hsa-mir-199a-2
(2692 sentences)


3282236 reads, 10210 reads per million, 151 experiments

aggaa   u  ggaga    -    c   gcC       U        C   U  --  ac 
     gcu cu     uccu gcuc guc   CCAGUGU CAGACUAC UGU Ca  gg  a
     ||| ||     |||| |||| |||   ||||||| |||||||| ||| ||  ||   
     cga ga     ggga cggg cag   GGUUACA GUCUGAUG ACA gu  cc  a
----a   -  -----    a    u   AUU       C        -   u  ug  gu 

Annotation confidence High
Do you think this miRNA is real?
Lagos-Quintana et al. [1] cloned miR-199 from human osteoblast sarcoma cells. They also reported identification of a miRNA from the opposite arm in mouse cells. This sequence was named miR-199-s and the sequence from the 3' arm of the homologous mouse precursor miR-199-as. Lim et al. [2] independently predicted this miRNA computationally using conservation with mouse and Fugu rubripes sequences [2]. Expression of the miR excised from the 5' arm was validated in zebrafish, and the ends mapped by cloning. The excised miR sequences are renamed miR-199a (to avoid confusion with the subsequently identified miR-199b (MIR:MI0000282)) and miR-199a* (from the 3' arm) here. The two putative hairpin precursors in human map to chromosome 19 (mir-199a-1, MIR:MI0000242) and chromosome 1 (mir-199a-2, MIR:MI0000281). Landgraf et al. show that both mature products are expressed, prompting the renaming to miR-199a-5p and miR-199a-3p [4].

Genome context
chr1: 172144535-172144644 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-199a-2
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-199a-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-199a-5p

Accession MIMAT0000231
Description Homo sapiens hsa-miR-199a-5p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets

Mature hsa-miR-199a-3p

Accession MIMAT0000232
Description Homo sapiens hsa-miR-199a-3p mature miRNA
Evidence experimental
cloned [4], Illumina [5]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  4. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  5. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179