Stem-loop hsa-let-7i

Accession

MI0000434

Symbol

HGNC: MIRLET7I

Description

Homo sapiens hsa-let-7i precursor miRNA

Literature search

1093 open access papers mention hsa-let-7i
(6021 sentences)

Sequence

1571181 reads, 6607 reads per million, 138 experiments

cuggcUGAGGUAGUAGUUUGUGCUGUUggucggguugugacauugcccgcuguggagauaaCUGCGCAAGCUACUGCCUUGCUa
.((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))

Structure

c    U                 U   --------  u     ugu 
 uggc GAGGUAGUAGUUUGUGC GUU        gg cgggu   g
 |||| ||||||||||||||||| |||        || |||||   a
 aUCG UUCCGUCAUCGAACGCG Caa        uc gcccg   c
-    -                 U   uagaggug  -     uua 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

chr12: 62603686-62603769 [+]

Disease association

hsa-let-7i is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-let-7i-5p

• Accession: MIMAT0000415
• Description: Homo sapiens hsa-let-7i-5p mature miRNA
• Sequence: 6 - UGAGGUAGUAGUUUGUGCUGUU - 27
• Evidence: experimental ; cloned [2-3], Illumina [5]

Mature hsa-let-7i-3p

• Accession: MIMAT0004585
• Description: Homo sapiens hsa-let-7i-3p mature miRNA
• Sequence: 62 - CUGCGCAAGCUACUGCCUUGCU - 83
• Evidence: experimental ; cloned [2-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 17989717
   Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
   "Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A"
   "Leukemia (2008) 22:330-338


4. PubMed ID: 20158877
   Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
   Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
   BMC Genomics (2010) 11:S6


5. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739