miRBase entry: hsa-let-7i

Stem-loop hsa-let-7i

Homo sapiens hsa-let-7i precursor miRNA
Gene family
MIPF0000002; let-7

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIRLET7I is a microRNA that is downregulated in various diseases, including gastric cancer, ovarian cancer, sepsis, and HIV-1 infection [PMC9708458] [PMC6960189] [PMC8358855] [PMC6701281] [PMC4052096]. It is located in a CpG island and its expression can be regulated by epigenetic mechanisms [PMC9708458]. Two single nucleotide polymorphisms (SNPs), rs10877887 and rs13293512, are found in the promoter regions of MIRLET7I and the MIRLET7A1/MIRLET7F1/MIRLET7D cluster, respectively [PMC9708458]. Overexpression of MIRLET7I has been achieved using pCMV-MIR vectors in various cell lines [PMC6960189]. In sepsis patients, MIRLET7I expression is reduced compared to controls and has been proposed as a potential biomarker for sepsis diagnosis and prognosis [PMC8358855]. In ovarian cancer patients, MIRLET7I is significantly downregulated and can discriminate between benign and malignant ovarian disease [PMC6701281]. Bioinformatic analysis has shown that MIRLET7I targets genes related to cardiovascular development [PMC7912193]. In HIV-1 infection, dysregulation of MIRLET7I contributes to viral replication through DNA hypermethylation and immune system dysfunction. It also regulates the Vif/Vpr protein involved in immune response induction during the intermediate HIV infection stage. The high homology between MIRLET7I sequences and HIV-1 sequences supports its involvement in viral replication regulation during infection stages.

Literature search
1093 open access papers mention hsa-let-7i
(6021 sentences)


1571183 reads, 7403 reads per million, 138 experiments

c    U                 U   --------  u     ugu 
 uggc GAGGUAGUAGUUUGUGC GUU        gg cgggu   g
 |||| ||||||||||||||||| |||        || |||||   a
 aUCG UUCCGUCAUCGAACGCG Caa        uc gcccg   c
-    -                 U   uagaggug  -     uua 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context
chr12: 62603686-62603769 [+]

Disease association
hsa-let-7i is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-let-7i-5p

Accession MIMAT0000415
Description Homo sapiens hsa-let-7i-5p mature miRNA
Evidence experimental
cloned [2-3], Illumina [5]
Database links
Predicted targets

Mature hsa-let-7i-3p

Accession MIMAT0004585
Description Homo sapiens hsa-let-7i-3p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 17989717
    Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
    "Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A"
    "Leukemia (2008) 22:330-338

  4. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739