Accession
MI0000434
Symbol
HGNC:
MIRLET7I
Description
Homo sapiens
hsa-let-7i precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7I is a microRNA that is downregulated in various diseases, including gastric cancer, ovarian cancer, sepsis, and HIV-1 infection [PMC9708458] [PMC6960189] [PMC8358855] [PMC6701281] [PMC4052096]. It is located in a CpG island and its expression can be regulated by epigenetic mechanisms [PMC9708458]. Two single nucleotide polymorphisms (SNPs), rs10877887 and rs13293512, are found in the promoter regions of MIRLET7I and the MIRLET7A1/MIRLET7F1/MIRLET7D cluster, respectively [PMC9708458]. Overexpression of MIRLET7I has been achieved using pCMV-MIR vectors in various cell lines [PMC6960189]. In sepsis patients, MIRLET7I expression is reduced compared to controls and has been proposed as a potential biomarker for sepsis diagnosis and prognosis [PMC8358855]. In ovarian cancer patients, MIRLET7I is significantly downregulated and can discriminate between benign and malignant ovarian disease [PMC6701281]. Bioinformatic analysis has shown that MIRLET7I targets genes related to cardiovascular development [PMC7912193]. In HIV-1 infection, dysregulation of MIRLET7I contributes to viral replication through DNA hypermethylation and immune system dysfunction. It also regulates the Vif/Vpr protein involved in immune response induction during the intermediate HIV infection stage. The high homology between MIRLET7I sequences and HIV-1 sequences supports its involvement in viral replication regulation during infection stages.
Literature search
1093 open access papers mention hsa-let-7i
(6021 sentences)
(6021 sentences)
Sequence
1571183
reads,
7403
reads per million, 138 experiments
cuggcUGAGGUAGUAGUUUGUGCUGUUggucggguugugacauugcccgcuguggagauaaCUGCGCAAGCUACUGCCUUGCUa
.((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))
.((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))
Structure
c U U -------- u ugu uggc GAGGUAGUAGUUUGUGC GUU gg cgggu g |||| ||||||||||||||||| ||| || ||||| a aUCG UUCCGUCAUCGAACGCG Caa uc gcccg c - - U uagaggug - uua
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].
Genome context
chr12: 62603686-62603769 [+]
Disease association
hsa-let-7i is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-let-7i-5p
| Accession | MIMAT0000415 |
| Description | Homo sapiens hsa-let-7i-5p mature miRNA |
| Sequence | 6 - UGAGGUAGUAGUUUGUGCUGUU - 27 |
| Evidence |
experimental
cloned [2-3], Illumina [5] |
| Database links |
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| Predicted targets |
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Mature hsa-let-7i-3p
| Accession | MIMAT0004585 |
| Description | Homo sapiens hsa-let-7i-3p mature miRNA |
| Sequence | 62 - CUGCGCAAGCUACUGCCUUGCU - 83 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
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| Predicted targets |
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References
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