MIR125B2 is a microRNA gene implicated in the genetic investigation of anterior cruciate ligament (ACL) rupture due to its potential pathogenicity and shared biology with other associated genes [PMC9536556]. Single nucleotide polymorphisms (SNPs) in the genomic DNA of offspring were utilized to determine the imprinting status of MIR125B2, indicating its potential involvement in genetic inheritance patterns [PMC10014956]. The gene was selected among others for its relevance to ACL rupture, based on shared regions in affected family members, previously published associations, and common biological functions [PMC9536556].
a aga u - U C A g auu cc cuuu ccuag UCCC GAGA CCU ACUUGUGA gu u || |||| ||||| |||| |||| ||| |||||||| || u gg gagg ggauc AGGG UUCU GGA UGAACACU ca a a --g c C - C C a aug
Disease | Description | Category | PubMed ID |
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Accession | MIMAT0000423 |
Description | Homo sapiens hsa-miR-125b-5p mature miRNA |
Sequence | 17 - UCCCUGAGACCCUAACUUGUGA - 38 |
Evidence |
experimental
cloned [2,4-6], Illumina [7] |
Database links |
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Predicted targets |
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Accession | MIMAT0004603 |
Description | Homo sapiens hsa-miR-125b-2-3p mature miRNA |
Sequence | 54 - UCACAAGUCAGGCUCUUGGGAC - 75 |
Evidence |
experimental
cloned [5] |
Database links |
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Predicted targets |
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