Stem-loop mmu-mir-34a

Accession

MI0000584

Symbol

MGI: Mir34a

Description

Mus musculus mmu-mir-34a precursor miRNA mir-34

Gene
family

RF00456; mir-34

Literature search

388 open access papers mention mmu-mir-34a
(5566 sentences)

Sequence

36318 reads, 336 reads per million, 104 experiments

ccagcugugaguaauucuuUGGCAGUGUCUUAGCUGGUUGUugugaguauuagcuaaggaagcAAUCAGCAAGUAUACUGCCCUagaagugcugcacauugu
.(((.((((((((.((((..(((((((((((.((((((((((...(((....))).....))))))))))))).))))))))..)))).)))).))))))).

Structure

c   c    -    a    uU        -   A          --gug   a 
 cag ugug agua uucu  GGCAGUGU CUU GCUGGUUGUu     agu u
 ||| |||| |||| ||||  |||||||| ||| ||||||||||     |||  
 guu acac ucgu aaga  CCGUCAUA GAA CGACUAAcga     ucg u
u   -    g    g    UC        U   -          aggaa   a 

Annotation confidence High

Comments

Houbaviy et al. cloned this miRNA from embryonic stem cells and named it miR-172 [1]. This sequence is homologous to human miR-34a (MIR:MI0000268), and so is renamed miR-34a here. This sequence is not related to miR172 from plants (MIR:MI0000215 and MIR:MI0000216). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr4: 150068454-150068555 [+]

Mature mmu-miR-34a-5p

• Accession: MIMAT0000542
• Description: Mus musculus mmu-miR-34a-5p mature miRNA
• Sequence: 20 - UGGCAGUGUCUUAGCUGGUUGU - 41
• Evidence: experimental ; cloned [1,3], Illumina [4,6]

Mature mmu-miR-34a-3p

• Accession: MIMAT0017022
• Description: Mus musculus mmu-miR-34a-3p mature miRNA
• Sequence: 64 - AAUCAGCAAGUAUACUGCCCU - 84
• Evidence: experimental ; 454 [5], Illumina [6]

References

1. PubMed ID: 12554860
   Numerous microRNPs in neuronal cells containing novel microRNAs
   "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
   "RNA (2003) 9:180-186


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


6. PubMed ID: 20668074
   Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68
   "Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H"
   "J Virol (2010) 84:10266-10275