Accession
MI0000650
Symbol
HGNC:
MIR200C
Description
Homo sapiens
hsa-mir-200c precursor miRNA mir-8
Gene
family?
family?
RF00241;
mir-8
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-200c is a microRNA implicated in the regulation of gene expression through its interaction with the 3′ untranslated regions (3′UTRs) of target mRNAs [PMC2133370]. Research has identified the 3′UTR of glutathione S-transferase mu 3 (GSTM3) as a direct target of hsa-mir-200c, as evidenced by experiments involving co-transfection with scrambled control siRNA and various GSTM3 3′UTR plasmids [PMC9688189]. Clinical data further suggest that hsa-mir-200c levels may have prognostic significance, with patients exhibiting lower expression levels of this microRNA having a longer average survival period by approximately 12 months compared to those with higher expression levels [PMC2133370]. This correlation between hsa-mir-200c expression and patient survival underscores the potential importance of this microRNA in disease progression and patient outcomes.
Literature search
729 open access papers mention hsa-mir-200c
(4951 sentences)
(4951 sentences)
Sequence
285921
reads,
2318
reads per million, 157 experiments
cccuCGUCUUACCCAGCAGUGUUUGGgugcgguugggagucucUAAUACUGCCGGGUAAUGAUGGAgg
.(((((((((((((.((((((((.(((.((........))))).)))))))).)))))).))).))))
.(((((((((((((.((((((((.(((.((........))))).)))))))).)))))).))).))))
Structure
c - - A U u ggu ccuC GUC UUACCC GCAGUGUU GGg gc u |||| ||| |||||| |||||||| ||| || ggAG UAG AAUGGG CGUCAUAA cuc ug g - G U C U - agg
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr12: 6963699-6963766 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-200c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-200c is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-200c is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-200c is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-200c-5p
| Accession | MIMAT0004657 |
| Description | Homo sapiens hsa-miR-200c-5p mature miRNA |
| Sequence | 5 - CGUCUUACCCAGCAGUGUUUGG - 26 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-200c-3p
| Accession | MIMAT0000617 |
| Description | Homo sapiens hsa-miR-200c-3p mature miRNA |
| Sequence | 44 - UAAUACUGCCGGGUAAUGAUGGA - 66 |
| Evidence |
experimental
cloned [1-4], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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