Stem-loop hsa-mir-374a

Accession

MI0000782

Symbol

HGNC: MIR374A

Description

Homo sapiens hsa-mir-374a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR374A is a microRNA that has been identified as a direct regulator of the p140Cap protein in lung, gastric, and cutaneous squamous carcinoma cells, linking miRNAs to epithelial cancer cell features through the inhibition of p140Cap expression [PMC5357316]. It is part of a panel of nine miRNAs, including miR-21, miR-218, miR-193b, miR-331, MIR374A, miR548c, miR520f, miR27b and miR-30b that have been associated with tumor volume and shown to have a 67% sensitivity and 80% specificity [PMC9965735]. MIR374A has also been detected in cerebrospinal fluid (CSF) samples from glioblastoma patients and found to correlate with levels detected from tissue biopsies [PMC7014190]. It has been associated with malignancy and identified as an independent predictor for LOFS (loss of fetal signal) when combined with MIR320b [PMC6196565]. In addition to its role in cancer cells, MIR374A has also been implicated in distinguishing hypoxic-ischemic encephalopathy (HIE) patients from healthy newborns and assessing the severity of HIE [PMC7296108]. Furthermore, MIR374A is involved in autophagy regulation by targeting RAB5A and UVRAG genes [PMC4389881]. Overall, MIR374A plays a role in various biological processes including cancer development and progression as well as HIE severity assessment.

Literature search

67 open access papers mention hsa-mir-374a
(407 sentences)

Sequence

165954 reads, 1036 reads per million, 146 experiments

uacaucggccaUUAUAAUACAACCUGAUAAGUGuuauagcaCUUAUCAGAUUGUAUUGUAAUUgucugugua
(((((.(((.((((((((((((.(((((((((((....))))))))))).)))))))))))).))).)))))

Structure

     c   c            C           u 
uacau ggc aUUAUAAUACAA CUGAUAAGUGu a
||||| ||| |||||||||||| |||||||||||  
augug cug UAAUGUUAUGUU GACUAUUCacg u
     u   U            A           a 

Annotation confidence High

Genome context

chrX: 74287286-74287357 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-374a

Disease association

hsa-mir-374a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-374a-5p

• Accession: MIMAT0000727
• Description: Homo sapiens hsa-miR-374a-5p mature miRNA
• Sequence: 12 - UUAUAAUACAACCUGAUAAGUG - 33
• Evidence: experimental ; cloned [1-4], Northern [1]

Mature hsa-miR-374a-3p

• Accession: MIMAT0004688
• Description: Homo sapiens hsa-miR-374a-3p mature miRNA
• Sequence: 42 - CUUAUCAGAUUGUAUUGUAAUU - 63
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 15183728
   Human embryonic stem cells express a unique set of microRNAs
   "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
   "Dev Biol (2004) 270:488-498


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267