Stem-loop hsa-mir-423

Accession

MI0001445

Symbol

HGNC: MIR423

Description

Homo sapiens hsa-mir-423 precursor miRNA mir-423

Gene
family

RF00870; mir-423

Literature search

111 open access papers mention hsa-mir-423
(452 sentences)

Sequence

1378741 reads, 3190 reads per million, 159 experiments

auaaaggaaguuaggcUGAGGGGCAGAGAGCGAGACUUUucuauuuuccaaaAGCUCGGUCUGAGGCCCCUCAGUcuugcuuccuaacccgcgc
....(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).))))))).........

Structure

-----auaa       u            -AG   G    A     cua 
         aggaagu aggcUGAGGGGC   AGA CGAG CUUUu   u
         ||||||| ||||||||||||   ||| |||| |||||   u
         uccuucg ucUGACUCCCCG   UCU GCUC GAaaa   u
cgcgcccaa       u            GAG   G    -     ccu 

Annotation confidence High

Comments

miR-423 (renamed miR-423-3p here) is expressed in human promyelocytic leukemia (HL-60) cells [1]. The level of expression was shown to be up-regulated 48 hours after TPA-induction. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr17: 30117079-30117172 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-423

Disease association

hsa-mir-423 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-423-5p

• Accession: MIMAT0004748
• Description: Homo sapiens hsa-miR-423-5p mature miRNA
• Sequence: 17 - UGAGGGGCAGAGAGCGAGACUUU - 39
• Evidence: experimental ; cloned [2-4], Northern [4], Illumina [5]

Mature hsa-miR-423-3p

• Accession: MIMAT0001340
• Description: Homo sapiens hsa-miR-423-3p mature miRNA
• Sequence: 53 - AGCUCGGUCUGAGGCCCCUCAGU - 75
• Evidence: experimental ; cloned [1-2], Northern [1]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 20158877
   Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
   Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
   BMC Genomics (2010) 11:S6


5. PubMed ID: 18230126
   New miRNAs cloned from neuroblastoma
   "Afanasyeva EA, Hotz-Wagenblatt A, Glatting KH, Westermann F"
   "BMC Genomics (2008) 9:52