Stem-loop hsa-mir-1271

Accession

MI0003814

Symbol

HGNC: MIR1271

Description

Homo sapiens hsa-mir-1271 precursor miRNA mir-1271

Gene
family

RF04085; mir-1271

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1271 is a tumor suppressor in hepatocellular carcinoma (HCC) [PMC7425487]. A negative correlation has been established between FOXK2 mRNA and MIR1271 in HCC patient samples [PMC6468357]. MIR1271 directly regulates CCNG1, a master tumor suppressor [PMC5772750]. In various tumors, MIR1271 also directly regulates LDHA, along with miR-200c, miR-449a, miR-30d-5p, miR-142-3p, and miR-383 [PMC9742379]. Bioinformatics analysis of the MIR1271 gene has identified genehancers using the genehancer v4.8 database [PMC8454712]. Additionally, in osteoarthritis (OA) progression, circSERPINE2 functions as a competing endogenous RNA (ceRNA) of MIR1271 to regulate the anabolism of the extracellular matrix (ECM) [PMC7393488].

Literature search

19 open access papers mention hsa-mir-1271
(34 sentences)

Sequence

15918 reads, 246 reads per million, 121 experiments

cacccagaucagugCUUGGCACCUAGCAAGCACUCAguaaauauuuguugAGUGCCUGCUAUGUGCCAGGCAuugugcugagggcu
..(((((..(((((((((((((.(((((.(((((((((((....))))))))))).))))).)))))))))))))..))).))...

Structure

-ca  -   au             C     A           a 
   cc cag  cagugCUUGGCAC UAGCA GCACUCAguaa u
   || |||  ||||||||||||| ||||| |||||||||||  
   gg guc  guuACGGACCGUG AUCGU CGUGAguuguu a
ucg  a   gu             U     C           u 

Annotation confidence High

Genome context

chr5: 176367946-176368031 [+]

Disease association

hsa-mir-1271 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1271-5p

• Accession: MIMAT0005796
• Description: Homo sapiens hsa-miR-1271-5p mature miRNA
• Sequence: 15 - CUUGGCACCUAGCAAGCACUCA - 36
• Evidence: experimental ; Illumina [2], 454 [3]

Mature hsa-miR-1271-3p

• Accession: MIMAT0022712
• Description: Homo sapiens hsa-miR-1271-3p mature miRNA
• Sequence: 51 - AGUGCCUGCUAUGUGCCAGGCA - 72
• Evidence: not_experimental

References

1. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


2. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621


3. PubMed ID: 19508715
   Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing
   Nygaard S, Jacobsen A, Lindow M, Eriksen J, Balslev E, Flyger H, Tolstrup N, Møller S, Krogh A, Litman T
   BMC Med Genomics (2009) 2:35