Stem-loop mdv1-mir-M4

Accession

MI0005096

Description

Mareks disease virus type 1 mdv1-mir-M4 precursor miRNA

Sequence

gaaguUUAAUGCUGUAUCGGAACCCUUCguucggugaccacgAAUGGUUCUGACAGCAUGACCuuu
((((....((((((..((((((((.(((((..((...))))))).))))))))))))))...))))

Structure

    uUUA      UA        C     uc  u 
gaag    AUGCUG  UCGGAACC UUCgu  gg  
||||    ||||||  |||||||| |||||  || g
uuuC    UACGAC  AGUCUUGG AAgca  cc  
    -CAG      --        U     --  a 

Annotation confidence Not enough data

Genome context

AF243438.1: 7192-7257 [-]

Clustered miRNAs

8 other miRNAs are < 10 kb from mdv1-mir-M4

Disease association

mdv1-mir-M4 is associated with one or more human diseases in the Human microRNA Disease Database

Mature mdv1-miR-M4-5p

• Accession: MIMAT0003924
• Description: Mareks disease virus type 1 mdv1-miR-M4-5p mature miRNA
• Sequence: 6 - UUAAUGCUGUAUCGGAACCCUUC - 28
• Evidence: experimental ; cloned [1-3], Northern [1-2], Illumina [4]

Mature mdv1-miR-M4-3p

• Accession: MIMAT0003925
• Description: Mareks disease virus type 1 mdv1-miR-M4-3p mature miRNA
• Sequence: 43 - AAUGGUUCUGACAGCAUGACC - 63
• Evidence: experimental ; cloned [1-3], Northern [1-2], Illumina [4]

References

1. PubMed ID: 18256158
   MicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAs
   "Yao Y, Zhao Y, Xu H, Smith LP, Lawrie CH, Watson M, Nair V"
   "J Virol (2008) 82:4007-4015


2. PubMed ID: 16912324
   Marek's disease virus encodes MicroRNAs that map to meq and the latency-associated transcript
   "Burnside J, Bernberg E, Anderson A, Lu C, Meyers BC, Green PJ, Jain N, Isaacs G, Morgan RW"
   "J Virol (2006) 80:8778-8786


3. PubMed ID: 18430245
   Deep sequencing of chicken microRNAs
   Burnside J, Ouyang M, Anderson A, Bernberg E, Lu C, Meyers BC, Green PJ, Markis M, Isaacs G, Huang E, Morgan RW
   BMC Genomics (2008) 9:185


4. PubMed ID: 18842708
   Sequence conservation and differential expression of Marek's disease virus microRNAs
   "Morgan R, Anderson A, Bernberg E, Kamboj S, Huang E, Lagasse G, Isaacs G, Parcells M, Meyers BC, Green PJ, Burnside J"
   "J Virol (2008) 82:12213-12220